The activation of T cells requires the entry of calcium ions through the plasma membrane. A study now identifies a voltage-gated sodium channel as being essential for the sustained entry of calcium needed for the developmental process of positive selection.
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Malissen, B. A voltage-gated sodium channel mediates positive selection of T cells. Nat Immunol 13, 810–812 (2012). https://doi.org/10.1038/ni.2400
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DOI: https://doi.org/10.1038/ni.2400