T-cell receptor

Definition

T-cell receptors (TCRs) recognize small protein fragments (peptides) that are displayed on the surface of antigen-presenting cells. Each T cell expresses a unique TCR that is generated by randomly assorting genes. This ensures that T cells can respond (at the population level) to almost any infection.

Latest Research and Reviews

  • Research |

    The phosphatase calcineurin targets NFAT transcription factors in T cells. Ashwell and colleagues show that calcineurin is recruited to the TCR signaling complex, where it reverses the inhibitory phosphorylation of the kinase Lck.

    • Debjani Dutta
    • , Valarie A Barr
    • , Itoro Akpan
    • , Paul R Mittelstadt
    • , Laishram I Singha
    • , Lawrence E Samelson
    •  & Jonathan D Ashwell
    Nature Immunology 18, 196–204
  • Research |

    Analysis of T cells isolated from patients with and without type 1 diabetes reveals reactivity to a range of native as well as post-translationally modified self-antigens only in individuals with T1D.

    • Jenny Aurielle B Babon
    • , Megan E DeNicola
    • , David M Blodgett
    • , Inne Crèvecoeur
    • , Thomas S Buttrick
    • , René Maehr
    • , Rita Bottino
    • , Ali Naji
    • , John Kaddis
    • , Wassim Elyaman
    • , Eddie A James
    • , Rachana Haliyur
    • , Marcela Brissova
    • , Lut Overbergh
    • , Chantal Mathieu
    • , Thomas Delong
    • , Kathryn Haskins
    • , Alberto Pugliese
    • , Martha Campbell-Thompson
    • , Clayton Mathews
    • , Mark A Atkinson
    • , Alvin C Powers
    • , David M Harlan
    •  & Sally C Kent
    Nature Medicine 22, 1482–1487
  • Research | | open

    Naïve T cells establish self-tolerance via negative selection of cells with strong reactivity for self-peptide/MHC complexes, but undergo T-cell receptor (TCR) desensitisation when leaving the thymus. Here, Cho et al. show that TCR desensitisation correlates with cell-surface density of the phosphatase CD45.

    • Jae-Ho Cho
    • , Hee-Ok Kim
    • , Young-Jun Ju
    • , Yoon-Chul Kye
    • , Gil-Woo Lee
    • , Sung-Woo Lee
    • , Cheol-Heui Yun
    • , Nunzio Bottini
    • , Kylie Webster
    • , Christopher C. Goodnow
    • , Charles D. Surh
    • , Cecile King
    •  & Jonathan Sprent
  • Research | | open

    Germline-encoded mycolyl lipid-reactive (GEM) T cells recognize CD1b proteins presenting mycobacterial mycolates via their T-cell receptors (TCRs). Here, the authors present the structure of this interaction and provide a molecular basis for the co-recognition of CD1b and a mycobacterial glycolipid.

    • Stephanie Gras
    • , Ildiko Van Rhijn
    • , Adam Shahine
    • , Tan-Yun Cheng
    • , Mugdha Bhati
    • , Li Lynn Tan
    • , Hanim Halim
    • , Kathryn D. Tuttle
    • , Laurent Gapin
    • , Jérôme Le Nours
    • , D. Branch Moody
    •  & Jamie Rossjohn

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