Calcium signalling

Definition

Calcium signalling is activated by calcium ions that are released from intracellular stores, or enter the cell via plasma membrane ion channels. Calcium is an important second messenger that regulates many cellular activities, including fertilisation, secretion, neurotransmission and cell migration.

Latest Research and Reviews

  • Research | | open

    The mitochondrial uniporter MICU1 regulates mitochondrial Ca2+ uptake. Here, the authors show that MICU1 is upregulated in ovarian cancer and confers resistance to cisplatin-induced apoptosis through a Ca2+-mediated regulation of pyruvate dehydrogenase activity that results in increased glycolysis.

    • Prabir K. Chakraborty
    • , Soumyajit Banerjee Mustafi
    • , Xunhao Xiong
    • , Shailendra Kumar Dhar Dwivedi
    • , Vasyl Nesin
    • , Sounik Saha
    • , Min Zhang
    • , Danny Dhanasekaran
    • , Muralidharan Jayaraman
    • , Robert Mannel
    • , Kathleen Moore
    • , Scott McMeekin
    • , Da Yang
    • , Rosemary Zuna
    • , Kai Ding
    • , Leonidas Tsiokas
    • , Resham Bhattacharya
    •  & Priyabrata Mukherjee
  • Research | | open

    Regulatory T cells (Tregs) promote immune suppression in the tumour. Here, the authors show that Tregs suppress cytotoxic T lymphocyte (CTL) activity by impairing Ca2+ signalling and that adoptive transfer of CTLs engineered with an optogenetic control of Ca2+ overcome the immune suppression at the tumour site.

    • Kyun-Do Kim
    • , Seyeon Bae
    • , Tara Capece
    • , Hristina Nedelkovska
    • , Rafael G. de Rubio
    • , Alan V. Smrcka
    • , Chang-Duk Jun
    • , Woojin Jung
    • , Byeonghak Park
    • , Tae-il Kim
    •  & Minsoo Kim
  • Research |

    Conditional deletion of the mitochondrial Na+/Ca2+ exchanger NCLX in adult mouse hearts causes sudden death due to mitochondrial calcium overload, whereas its overexpression limits cell death elicited by ischaemia reperfusion injury and heart failure.

    • Timothy S. Luongo
    • , Jonathan P. Lambert
    • , Polina Gross
    • , Mary Nwokedi
    • , Alyssa A. Lombardi
    • , Santhanam Shanmughapriya
    • , April C. Carpenter
    • , Devin Kolmetzky
    • , Erhe Gao
    • , Jop H. van Berlo
    • , Emily J. Tsai
    • , Jeffery D. Molkentin
    • , Xiongwen Chen
    • , Muniswamy Madesh
    • , Steven R. Houser
    •  & John W. Elrod
    Nature 545, 93–97
  • Reviews |

    Changes in the calcium signal enable cells to achieve specific outcomes. In this Review, Monteith et al. describe how the remodelling of the expression and activity of calcium channels and pumps in cancer cells can influence tumour progression.

    • Gregory R. Monteith
    • , Natalia Prevarskaya
    •  & Sarah J. Roberts-Thomson
    Nature Reviews Cancer 17, 367–380

News and Comment