Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
The thymus is considered the source of mature lymphocytes and is not thought to produce progenitors with the capacity to develop into unconventional T cells in the periphery. That view requires revision.
Discrimination between self and bacterial DNA has been attributed in part to differential modification of prokaryotic and eukaryotic DNA. However, cellular localization of innate DNA receptors may be even more important.
The function of TRAF3, a member of the family of tumor necrosis factor receptor–associated factors, has remained an enigma. Two recent Nature papers now show that TRAF3 regulates interferon and interleukin 10 production.