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Orchestrated leak provokes a thymus reassessment

The thymus is considered the source of mature lymphocytes and is not thought to produce progenitors with the capacity to develop into unconventional T cells in the periphery. That view requires revision.

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Figure 1: In the current view (left), bone marrow–derived or fetal liver–derived hematopoietic stem cells (HSC) enter the thymus, where stromal signals induce T cell commitment and differentiation.

Katie Ris

References

  1. Macpherson, A.J. et al. Immunology 115, 153–162 (2005).

    Article  CAS  Google Scholar 

  2. Hayday, A. et al. Nat. Immunol. 2, 997–1003 (2001).

    Article  CAS  Google Scholar 

  3. Rocha, B. et al. J. Exp. Med. 173, 483–486 (1991).

    Article  CAS  Google Scholar 

  4. Lambolez, F. et al. Nat. Immunol. 7, 76–82 (2006).

    Article  CAS  Google Scholar 

  5. Poussier, P. et al. J. Exp. Med. 195, 1491–1497 (2002).

    Article  CAS  Google Scholar 

  6. Silva-Santos, B. et al. Science 307, 925–928 (2005).

    Article  CAS  Google Scholar 

  7. Harman, B. et al. Blood 106, 886–892 (2005).

    Article  CAS  Google Scholar 

  8. Laky, K. et al. J.Exp. Med. 191, 1569–1580 (2000).

    Article  CAS  Google Scholar 

  9. Guy-Grand, D. et al. J. Exp. Med. 197, 333–341 (2003).

    Article  CAS  Google Scholar 

  10. Bas, A. et al. J. Immunol. 171, 3359–3371 (2003).

    Article  CAS  Google Scholar 

  11. Eberl, G. & Littman, D.R. Science 305, 248–251 (2004).

    Article  CAS  Google Scholar 

  12. Leishman, A. et al. Immunity 16, 355–364 (2002).

    Article  CAS  Google Scholar 

Download references

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Hayday, A. Orchestrated leak provokes a thymus reassessment. Nat Immunol 7, 9–11 (2006). https://doi.org/10.1038/ni0106-9

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