Discrimination between self and bacterial DNA has been attributed in part to differential modification of prokaryotic and eukaryotic DNA. However, cellular localization of innate DNA receptors may be even more important.
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Bauer, S. Toll-erating self DNA. Nat Immunol 7, 13–15 (2006). https://doi.org/10.1038/ni0106-13
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DOI: https://doi.org/10.1038/ni0106-13
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