Cold sensor identities in peripheral somatosensory neurons remain obscure. We show that GluK2, a kainate-type glutamate-sensing chemoreceptor that mediates synaptic transmission in the brain, mediates the sensing of cold but not cool temperatures in mouse dorsal root ganglia neurons in the periphery. Thus, we identify GluK2 as a cold-sensing thermoreceptor.
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References
Xiao, R. & Xu, X. Z. S. Temperature sensation: from molecular thermosensors to neural circuits and coding principles. Annu. Rev. Physiol. 83, 205–230 (2021). This review presents an overview of thermosensation.
Bautista, D. M. et al. The menthol receptor TRPM8 is the principal detector of environmental cold. Nature 448, 204–208 (2007). This paper shows that TRPM8 is required for cool sensing, but not cold sensing, in mice.
Dhaka, A. et al. TRPM8 is required for cold sensation in mice. Neuron 54, 371–378 (2007). This paper shows that TRPM8 is required for cool sensing, but not cold sensing, in mice.
Gong, J. et al. A cold-sensing receptor encoded by a glutamate receptor gene. Cell 178, 1375–1386.e11 (2019). This paper reports the identification of C. elegans GLR-3 as a cold sensor.
Valbuena, S. & Lerma, J. Non-canonical signaling, the hidden life of ligand-gated ion channels. Neuron 92, 316–329 (2016). This review presents an overview of ligand-gated ion channels (such as kainate receptors) that possess non-channel functions.
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This is a summary of: Cai, W. et al. The kainate receptor GluK2 mediates cold sensing in mice. Nat. Neurosci. https://doi.org/10.1038/s41593-024-01585-8 (2024).
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Identification of a cold sensor in peripheral somatosensory neurons. Nat Neurosci 27, 613–614 (2024). https://doi.org/10.1038/s41593-024-01606-6
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DOI: https://doi.org/10.1038/s41593-024-01606-6