Brain connections modulated by 534 deep-brain-stimulation electrodes revealed a gradient of circuits involved in dystonia, Parkinson’s disease, Tourette’s syndrome and obsessive-compulsive disorder. Together, these circuits begin to describe the human ‘dysfunctome’, a library of dysfunctional circuits that lead to various brain disorders.
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References
Hollunder, B. et al. Toward personalized medicine in connectomic deep brain stimulation. Prog. Neurobiol. 210, 102211 (2022). A perspective that proposes a circuit-based framework to optimize DBS outcomes.
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This is a summary of: Hollunder, B. et al. Mapping dysfunctional circuits in the frontal cortex using deep brain stimulation. Nat. Neurosci. https://doi.org/10.1038/s41593-024-01570-1 (2024).
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Mapping the dysfunctome provides an avenue for targeted brain circuit therapy. Nat Neurosci 27, 401–402 (2024). https://doi.org/10.1038/s41593-024-01572-z
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DOI: https://doi.org/10.1038/s41593-024-01572-z
