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Astrocyte biology

The silence of the reactive astrocytes

Nature Neuroscience volume 27, pages 607–609 (2024)Cite this article

Astrocytes have important roles in disease and are difficult to modulate, owing to a paucity of known targets. Clayton et al. develop a screening platform to unbiasedly identify modulators of astrocyte reactivity. They discover that HDAC3 inhibitors regulate astrocyte transitions into their reactive phenotype in vitro and in vivo.

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Fig. 1: Experimental workflow designed to understand the mechanisms that regulate the formation of neurotoxic reactive astrocytes and how to revert their phenotype.

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Authors and Affiliations

  1. Neuroscience Institute, NYU Grossman School of Medicine, New York, NY, USA

    Francesco Limone & Shane Liddelow

  2. Department of Neuroscience and Physiology, NYU Grossman School of Medicine, New York, NY, USA

    Shane Liddelow

Authors
  1. Francesco Limone
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  2. Shane Liddelow
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Correspondence to Shane Liddelow.

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Competing interests

S.L. declares ownership of AstronauTx Ltd. F.L. declares no competing interests.

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Limone, F., Liddelow, S. The silence of the reactive astrocytes. Nat Neurosci 27, 607–609 (2024). https://doi.org/10.1038/s41593-024-01593-8

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