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Glial lipid droplets resolve ROS during sleep

Nature Neuroscience volume 27, pages 610–612 (2024)Cite this article

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The Sehgal lab presents data showing that the non-cell autonomous pathway of glial lipid droplet formation occurs during sleep and helps to resolve neuronal reactive oxygen species (ROS). This promotes neuronal function after an active day. Hence, this pathway has an important physiological function beyond its previously described role in ROS-associated diseases, including Alzheimer’s disease.

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Fig. 1: Glial lipid droplets are formed during wake hours and catabolized during sleep to maintain proper neuronal function.

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Authors and Affiliations

  1. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA

    Lindsey D. Goodman, Matthew J. Moulton & Hugo J. Bellen

  2. Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX, USA

    Lindsey D. Goodman, Matthew J. Moulton & Hugo J. Bellen

  3. Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA

    Hugo J. Bellen

Authors
  1. Lindsey D. Goodman
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  2. Matthew J. Moulton
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  3. Hugo J. Bellen
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Correspondence to Hugo J. Bellen.

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Goodman, L.D., Moulton, M.J. & Bellen, H.J. Glial lipid droplets resolve ROS during sleep. Nat Neurosci 27, 610–612 (2024). https://doi.org/10.1038/s41593-023-01546-7

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