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Volume 3 Issue 7, July 2001

Part of the Drosophila abdomen in dark field, stained for Patched (blue), with hairs and bristles pointing straight down [Cover design: Majo Xeridat] [commentary, pE151]

Volume 3 Issue 7

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Article

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Erratum

    • Matthew L. Cheever
    • Trey K. Sato
    • Michael Overduin
    Erratum
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Article

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Brief Communication

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Editorial

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Commentary

  • Morphogens are in the front line just now. Here I trace how the concept of a morphogen has evolved over the past 100 years and step a little beyond what we already know.

    • Peter A. Lawrence
    Commentary

  • Since the discovery of substances in serum media that are able to drive cells into proliferation and/or differentiation, investigators have tried to understand how such signalling molecules can influence cells to change their behaviour. The complex nature of the responses to signals, and the equally complex signalling pathway leading to those responses, have made life difficult for the researcher. However, recent evidence obtained in genetic developmental systems indicates that a multiplicity of downstream events can be accomplished by regulation of the activity of just one transcription factor.

    • Marcel van den Heuvel
    Commentary
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News & Views

  • No mutation in the fibroblast-growth-factor receptor-4 (FGFR-4) signalling pathway has so far been associated with either heritable human diseases or cancer. A new study now implicates N-CAM–FGFR-4 signalling in the regulation of tumour-cell–matrix adhesion and in the metastatis of pancreatic β-cell tumours.

    • Kari Alitalo
    News & Views

  • Centrosomes define the poles of mitotic spindles, but spindles that lack centrosomes mediate meiotic chromosome segregation in females. Recent studies provide new insight into anastral-spindle assembly, and indicate that a conserved protein complex may be critical to the stability of both the astral- and anastral-spindle pole.

    • William E. Theurkauf
    News & Views

  • Signals generated by the tyrosine kinase receptor Met elicit a complex biological response including cell dissociation, migration, protection from apoptosis, proliferation and differentiation. Paradoxically, all these are triggered by phosphorylation of a single two-tyrosine motif in the Met receptor tail, docking multiple SH2 signal transducers. The precise amino acid sequence of the motif is an absolute requirement for fulfilling the response, showing that there is specificity in intracellular pathways.

    • Paolo M. Comoglio
    News & Views
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Book Review

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Historical Perspective

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Meeting Report

    • Vania Braga
    • Adrian J. Harwood
    Meeting Report
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Focus

  • This section contains all of the material on development published in Nature Cell Biology to date. This includes News and Views, Review articles, and, of course, original research papers. View the original focus issue from July 2001.

    Focus
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