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The endosomal system includes distinct endocytic compartments where decisions are made that determine the destinations of extracellular and plasma membrane materials that have been internalized. A new family of proteins has been found that governs the exit of material from one of these endocytic organelles, the endosomal recycling compartment (ERC).
In the Drosophila egg, during signalling through the epidermal growth factor (EGF) receptor, a conformational switch, which is dependent on mitogen-activated protein kinase (MAPK) leads to the Cf2 transcriptio-nal repressor being targeted for proteolysis. Recent work shows that this switch is catalysed by the Drosophila homologue of Pin1, a peptidyl-prolyl isomerase.
Time-lapse analyses of normal cellular behaviours and signalling by fibroblast growth factor (FGF) provide new insights into the cell motions and molecules that form the posterior nervous system.