Table of contents
April 2006, Volume 8 No 4 pp301-424
About the coverObituary
Shoichiro Tsukita 1953–2005 - p302
Werner W. Franke
doi:10.1038/ncb0406-302
Full Text - Shoichiro Tsukita 1953–2005 | PDF (104 KB) - Shoichiro Tsukita 1953–2005
News and Views
Deubiquitinating PCNA: a downside to DNA damage tolerance - pp303 - 305
Helle D. Ulrich
doi:10.1038/ncb0406-303
Monoubiquitination of the processivity clamp, PCNA, facilitates the replicative bypass of DNA lesions by recruiting damage-tolerant polymerases. In undamaged cells, deubiquitination of PCNA by the deubiquitinating enzyme USP1 reveals a possible safeguard mechanism against the mutagenic effect of these polymerases. Intriguingly, USP1 itself seems to be downregulated by a damage-induced autocatalytic cleavage event.
Full Text - Deubiquitinating PCNA: a downside to DNA damage tolerance | PDF (174 KB) - Deubiquitinating PCNA: a downside to DNA damage tolerance
See also: Article by Huang et al.
Chordin cleavage is sizzling - pp305 - 307
David Kimelman & Daniel P. Szeto
doi:10.1038/ncb0406-305
Bone Morphogenetic Protein (Bmp) signalling has a critical function in patterning vertebrate and invertebrate embryos. A key regulator of Bmp signalling is Chordin, which binds Bmps and prevents them from interacting with their receptors. Two new papers identify the Frizzled-related protein Sizzled as an unexpected regulator of Chordin stability.
Full Text - Chordin cleavage is sizzling | PDF (196 KB) - Chordin cleavage is sizzling
See also: Article by Muraoka et al.
Chromosomes walk the line - pp308 - 310
Duane A. Compton
doi:10.1038/ncb0406-308
During cell division, replicated DNA condenses into chromosomes that conspicuously align at the equator of the microtubule-based spindle. This alignment is important for accurate chromosome segregation to daughter cells and startling new data show that chromosomes cooperate with one another to achieve this alignment.
Full Text - Chromosomes walk the line | PDF (232 KB) - Chromosomes walk the line
Eisosomes: endocytic portals - p310
Sowmya Swaminathan
doi:10.1038/ncb0406-310
Full Text - Eisosomes: endocytic portals | PDF (161 KB) - Eisosomes: endocytic portals
Opening the door to CO2 - pp311 - 312
Laura Serna
doi:10.1038/ncb0406-311
Gas exchange between the plant and the atmosphere depends on the opening of pores located primarily on the surfaces of leaves. A protein that regulates pore opening in response to both atmospheric CO2 concentrations and blue light has now been identified.
Full Text - Opening the door to CO2 | PDF (271 KB) - Opening the door to CO2
See also: Letter by Hashimoto et al.
Oocytes originating from skin? - pp313 - 314
Hans R. Schöler & Guangming Wu
doi:10.1038/ncb0406-313
In mammals, the germ-cell lineage separates from the somatic lineages around the time of gastrulation. Primordial germ cells migrate to the developing gonads and become the source of future gametes. Surprisingly, skin stem cells also have the intrinsic ability to develop into oocytes.
Full Text - Oocytes originating from skin? | PDF (163 KB) - Oocytes originating from skin?
Pathways to silencing unite - p315
Sinéad Hayes
doi:10.1038/ncb0406-315
Full Text - Pathways to silencing unite | PDF (121 KB) - Pathways to silencing unite
Articles
Regulation of caveolar endocytosis by syntaxin 6-dependent delivery of membrane components to the cell surface - pp317 - 328
Amit Choudhury, David L. Marks, Kirsty M. Proctor, Gwyn W. Gould & Richard E. Pagano
doi:10.1038/ncb1380
Abstract - Regulation of caveolar endocytosis by syntaxin 6-dependent delivery of membrane components to the cell surface | Full Text - Regulation of caveolar endocytosis by syntaxin 6-dependent delivery of membrane components to the cell surface | PDF (5,641 KB) - Regulation of caveolar endocytosis by syntaxin 6-dependent delivery of membrane components to the cell surface | Supplementary information
Sizzled controls dorso-ventral polarity by repressing cleavage of the Chordin protein - pp329 - 340
Osamu Muraoka, Takashi Shimizu, Taijiro Yabe, Hideaki Nojima, Young-Ki Bae, Hisashi Hashimoto & Masahiko Hibi
doi:10.1038/ncb1379
Abstract - Sizzled controls dorso-ventral polarity by repressing cleavage of the Chordin protein | Full Text - Sizzled controls dorso-ventral polarity by repressing cleavage of the Chordin protein | PDF (2,801 KB) - Sizzled controls dorso-ventral polarity by repressing cleavage of the Chordin protein | Supplementary information
See also: News and Views by Kimelman & Szeto
Regulation of monoubiquitinated PCNA by DUB autocleavage - pp341 - 347
Tony T. Huang, Sebastian M.B. Nijman, Kanchan D. Mirchandani, Paul J. Galardy, Martin A. Cohn, Wilhelm Haas, Steven P. Gygi, Hidde L. Ploegh, René Bernards & Alan D. D'Andrea
doi:10.1038/ncb1378
Abstract - Regulation of monoubiquitinated PCNA by DUB autocleavage | Full Text - Regulation of monoubiquitinated PCNA by DUB autocleavage | PDF (1,931 KB) - Regulation of monoubiquitinated PCNA by DUB autocleavage | Supplementary information
See also: News and Views by Ulrich
The KLHL12–Cullin-3 ubiquitin ligase negatively regulates the Wnt–
-catenin pathway by targeting Dishevelled for degradation - pp348 - 357
Stephane Angers, Chris J. Thorpe, Travis L. Biechele, Seth J. Goldenberg, Ning Zheng, Michael J. MacCoss & Randall T. Moon
doi:10.1038/ncb1381
Abstract - The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-[beta]-catenin pathway by targeting Dishevelled for degradation | Full Text - The KLHL12–Cullin-3 ubiquitin ligase negatively regulates the Wnt–
-catenin pathway by targeting Dishevelled for degradation | PDF (2,840 KB) - The KLHL12–Cullin-3 ubiquitin ligase negatively regulates the Wnt–-catenin pathway by targeting Dishevelled for degradation | Supplementary information
GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks - pp358 - 366
Agnieszka Gambus, Richard C. Jones, Alberto Sanchez-Diaz, Masato Kanemaki, Frederick van Deursen, Ricky D. Edmondson & Karim Labib
doi:10.1038/ncb1382
Abstract - GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks | Full Text - GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks | PDF (5,731 KB) - GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks | Supplementary information
Letters
Coordination of microtubule and microfilament dynamics by Drosophila Rho1, Spire and Cappuccino - pp367 - 376
Alicia E. Rosales-Nieves, James E. Johndrow, Lani C. Keller, Craig R. Magie, Delia M. Pinto-Santini & Susan M. Parkhurst
doi:10.1038/ncb1385
First Paragraph - Coordination of microtubule and microfilament dynamics by : Drosophila: Rho1, Spire and Cappuccino | Full Text - Coordination of microtubule and microfilament dynamics by Drosophila Rho1, Spire and Cappuccino | PDF (2,823 KB) - Coordination of microtubule and microfilament dynamics by Drosophila Rho1, Spire and Cappuccino | Supplementary information
Immuno-electron tomography of ER exit sites reveals the existence of free COPII-coated transport carriers - pp377 - 383
Dagmar Zeuschner, Willie J.C. Geerts, Elly van Donselaar, Bruno M. Humbel, Jan W. Slot, Abraham J. Koster & Judith Klumperman
doi:10.1038/ncb1371
First Paragraph - Immuno-electron tomography of ER exit sites reveals the existence of free COPII-coated transport carriers | Full Text - Immuno-electron tomography of ER exit sites reveals the existence of free COPII-coated transport carriers | PDF (4,299 KB) - Immuno-electron tomography of ER exit sites reveals the existence of free COPII-coated transport carriers | Supplementary information
In vitro germline potential of stem cells derived from fetal porcine skin - pp384 - 390
Paul W. Dyce, Lihua Wen & Julang Li
doi:10.1038/ncb1388
First Paragraph - In vitro: germline potential of stem cells derived from fetal porcine skin | Full Text - In vitro germline potential of stem cells derived from fetal porcine skin | PDF (4,051 KB) - In vitro germline potential of stem cells derived from fetal porcine skin | Supplementary information
See also: News and Views by Schöler & Wu
Arabidopsis HT1 kinase controls stomatal movements in response to CO2 - pp391 - 397
Mimi Hashimoto, Juntaro Negi, Jared Young, Maria Israelsson, Julian I. Schroeder & Koh Iba
doi:10.1038/ncb1387
First Paragraph - Arabidopsis: HT1 kinase controls stomatal movements in response to CO: 2 | Full Text - Arabidopsis HT1 kinase controls stomatal movements in response to CO2 | PDF (2,097 KB) - Arabidopsis HT1 kinase controls stomatal movements in response to CO2 | Supplementary information
See also: News and Views by Serna
Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-
B activation - pp398 - 406
Chuan-Jin Wu, Dietrich B. Conze, Tao Li, Srinivasa M. Srinivasula & Jonathan D. Ashwell
doi:10.1038/ncb1384
First Paragraph - Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-[kappa]B activation | Full Text - Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-
B activation | PDF (917 KB) - Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-B activation | Supplementary information
Evidence for the existence of an HP1-mediated subcode within the histone code - pp407 - 415
Gwen Lomberk, Debora Bensi, Martín E. Fernandez-Zapico & Raul Urrutia
doi:10.1038/ncb1383
First Paragraph - Evidence for the existence of an HP1-mediated subcode within the histone code | Full Text - Evidence for the existence of an HP1-mediated subcode within the histone code | PDF (2,856 KB) - Evidence for the existence of an HP1-mediated subcode within the histone code | Supplementary information
DNA methyltransferases control telomere length and telomere recombination in mammalian cells - pp416 - 424
Susana Gonzalo, Isabel Jaco, Mario F. Fraga, Taiping Chen, En Li, Manel Esteller & María A. Blasco
doi:10.1038/ncb1386
First Paragraph - DNA methyltransferases control telomere length and telomere recombination in mammalian cells | Full Text - DNA methyltransferases control telomere length and telomere recombination in mammalian cells | PDF (4,162 KB) - DNA methyltransferases control telomere length and telomere recombination in mammalian cells | Supplementary information
