In mammals, the germ-cell lineage separates from the somatic lineages around the time of gastrulation. Primordial germ cells migrate to the developing gonads and become the source of future gametes. Surprisingly, skin stem cells also have the intrinsic ability to develop into oocytes.
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Schöler, H., Wu, G. Oocytes originating from skin?. Nat Cell Biol 8, 313–314 (2006). https://doi.org/10.1038/ncb0406-313
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DOI: https://doi.org/10.1038/ncb0406-313
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