Sustainable databases - p1311

doi:10.1038/ncb1206-1311

Although the flood of cell biological knowledge rises relentlessly, many databases face an uncertain future. Unless funding for essential bioinformatic resources is set in stone, the next storm may wash away the foundation of future cell biology research.

Full Text - Sustainable databases | PDF (496 KB) - Sustainable databases

Maintaining the Genome - p1312

Philip C Hanawalt reviews DNA Repair and Mutagenesis (Second Edition) by Errol Friedberg, Graham Walker, Wolfram Siede, Richard Wood, Roger Schultz & Tom Ellenberger

doi:10.1038/ncb1206-1312

Full Text - Maintaining the Genome | PDF (510 KB) - Maintaining the Genome

DNA replication timing: random thoughts about origin firing - pp1313 - 1316

Nicholas Rhind

doi:10.1038/ncb1206-1313

Regions of metazoan genomes replicate at defined times within S phase. This observation suggests that replication origins fire with a defined timing pattern that remains the same from cycle to cycle. However, an alterative model based on the stochastic firing of origins may also explain replication timing. This model assumes varying origin efficiency instead of a strict origin-timing programme. Here, we discuss the evidence for both models.

Full Text - DNA replication timing: random thoughts about origin firing | PDF (875 KB) - DNA replication timing: random thoughts about origin firing

Upgrading the BCL-2 Network - pp1317 - 1319

Heidi L. Galonek & J. Marie Hardwick

doi:10.1038/ncb1206-1317

The BCL-2 oncogene promotes cancer progression by prohibiting cell death. BCL-2-related regulators were once thought to constitute a simple, two-class system of anti-death and pro-death factors. New data delineate a multistep hierarchy of BCL-2-family protein interactions that are driven by signal-dependent pathways.

Full Text - Upgrading the BCL-2 Network | PDF (290 KB) - Upgrading the BCL-2 Network

eIF4A goes beyond translation - pp1319 - 1321

Markus Affolter & George Pyrowolakis

doi:10.1038/ncb1206-1319

A new study has revealed an unexpected role for eukaryotic translation initiation factor 4A (eIF4A) in suppressing Decapentaplegic (Dpp) signalling. On activation of Dpp signalling, eIF4A promotes degradation of the downstream signalling components Mad and Medea in a translation-independent manner.

Full Text - eIF4A goes beyond translation | PDF (236 KB) - eIF4A goes beyond translation

S100 chemokines mediate bookmarking of premetastatic niches - pp1321 - 1323

Shahin Rafii & David Lyden

doi:10.1038/ncb1206-1321

Primary tumours release soluble factors, including VEGF-A, TGF and TNF, which induce expression of the chemokines S100A8 and S100A9 in the myeloid and endothelial cells within the lung before tumour metastasis. These chemokine-activated premetastatic niches support adhesion and invasion of disseminating malignant cells, thereby establishing a fertile habitat for metastatic tumours.

Full Text - S100 chemokines mediate bookmarking of premetastatic niches | PDF (230 KB) - S100 chemokines mediate bookmarking of premetastatic niches

Voltage sparks a GPCR - pp1323 - 1325

Peter Stanfield

doi:10.1038/ncb1206-1323

The response of some G-protein coupled receptors (GPRCs) is affected by the voltage across the membrane in which they sit. A study now shows that gating currents, similar to those of ion channels, are associated with this alteration in GPRC activity. The currents depend on structural elements of the receptor that functionally couple to G proteins.

Full Text - Voltage sparks a GPCR | PDF (212 KB) - Voltage sparks a GPCR

Shaped to split - p1325

Sinéad Hayes

doi:10.1038/ncb1206-1325

Full Text - Shaped to split | PDF (154 KB) - Shaped to split

Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells - pp1327 - 1336

Jongdae Lee, Ji-Hun Mo, Kyoko Katakura, Irit Alkalay, Adam N. Rucker, Yu-Tsueng Liu, Hyun-Ku Lee, Carol Shen, Gady Cojocaru, Steve Shenouda, Martin Kagnoff, Lars Eckmann, Yinon Ben-Neriah & Eyal Raz

doi:10.1038/ncb1500

Abstract - | Full Text - Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells | PDF (1,957 KB) - Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells | Supplementary information

Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8–IRSp53 complex - pp1337 - 1347

Andrea Disanza, Sara Mantoani, Maud Hertzog, Silke Gerboth, Emanuela Frittoli, Anika Steffen, Kerstin Berhoerster, Hans-Juergen Kreienkamp, Francesca Milanesi, Pier Paolo Di Fiore, Andrea Ciliberto, Theresia E. B. Stradal & Giorgio Scita

doi:10.1038/ncb1502

Abstract - | Full Text - Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8–IRSp53 complex | PDF (2,853 KB) - Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8–IRSp53 complex | Supplementary information

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies - pp1348 - 1358

Hyungjin Kim, Mubina Rafiuddin-Shah, Ho-Chou Tu, John R. Jeffers, Gerard P. Zambetti, James J.-D. Hsieh & Emily H.-Y. Cheng

doi:10.1038/ncb1499

Abstract - | Full Text - Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies | PDF (1,552 KB) - Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies | Supplementary information

See also: News and Views by Galonek & Hardwick

Tyrosine phosphorylation controls PCNA function through protein stability - pp1359 - 1368

Shao-Chun Wang, Yusuke Nakajima, Yung-Luen Yu, Weiya Xia, Chun-Te Chen, Cheng-Chieh Yang, Eric W. McIntush, Long-Yuan Li, David H. Hawke, Ryuji Kobayashi & Mien-Chie Hung

doi:10.1038/ncb1501

Abstract - | Full Text - Tyrosine phosphorylation controls PCNA function through protein stability | PDF (1,560 KB) - Tyrosine phosphorylation controls PCNA function through protein stability | Supplementary information

Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis - pp1369 - 1375

Sachie Hiratsuka, Akira Watanabe, Hiroyuki Aburatani & Yoshiro Maru

doi:10.1038/ncb1507

First Paragraph - | Full Text - Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis | PDF (2,568 KB) - Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis | Supplementary information

See also: News and Views by Rafii & Lyden

Key components of the fission machinery are interchangeable - pp1376 - 1382

Jia-Shu Yang, Leiliang Zhang, Stella Y. Lee, Helge Gad, Alberto Luini & Victor W. Hsu

doi:10.1038/ncb1503

First Paragraph - | Full Text - Key components of the fission machinery are interchangeable | PDF (1,797 KB) - Key components of the fission machinery are interchangeable | Supplementary information

Exo70 interacts with the Arp2/3 complex and regulates cell migration - pp1383 - 1388

Xiaofeng Zuo, Jian Zhang, Ying Zhang, Shu-Chan Hsu, Daoguo Zhou & Wei Guo

doi:10.1038/ncb1505

First Paragraph - | Full Text - Exo70 interacts with the Arp2/3 complex and regulates cell migration | PDF (1,322 KB) - Exo70 interacts with the Arp2/3 complex and regulates cell migration | Supplementary information

Phospholipase C1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1B - pp1389 - 1397

Jang Hyun Choi, Hyeon Soo Kim, Sun-Hee Kim, Yong Ryoul Yang, Yun Soo Bae, Jong-Soo Chang, H. Moo Kwon, Sung Ho Ryu & Pann-Ghill Suh

doi:10.1038/ncb1509

First Paragraph - | Full Text - Phospholipase C1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1B | PDF (4,218 KB) - Phospholipase C1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1B | Supplementary information

A Wnt–Axin2–GSK3 cascade regulates Snail1 activity in breast cancer cells - pp1398 - 1406

Jong In Yook, Xiao-Yan Li, Ichiro Ota, Casey Hu, Hyun Sil Kim, Nam Hee Kim, So Young Cha, Joo Kyung Ryu, Yoon Jung Choi, Jin Kim, Eric R. Fearon & Stephen J. Weiss

doi:10.1038/ncb1508

First Paragraph - | Full Text - A Wnt–Axin2–GSK3 cascade regulates Snail1 activity in breast cancer cells | PDF (2,410 KB) - A Wnt–Axin2–GSK3 cascade regulates Snail1 activity in breast cancer cells | Supplementary information

A novel function of Drosophila eIF4A as a negative regulator of Dpp/BMP signalling that mediates SMAD degradation - pp1407 - 1414

Jinghong Li & Willis X. Li

doi:10.1038/ncb1506

First Paragraph - | Full Text - A novel function of Drosophila eIF4A as a negative regulator of Dpp/BMP signalling that mediates SMAD degradation | PDF (1,688 KB) - A novel function of Drosophila eIF4A as a negative regulator of Dpp/BMP signalling that mediates SMAD degradation | Supplementary information

See also: News and Views by Affolter & Pyrowolakis

Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination - pp1415 - 1423

Lucia Di Marcotullio, Elisabetta Ferretti, Azzura Greco, Enrico De Smaele, Agnese Po, Maria Anna Sico, Maurizio Alimandi, Giuseppe Giannini, Marella Maroder, Isabella Screpanti & Alberto Gulino

doi:10.1038/ncb1510

First Paragraph - | Full Text - Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination | PDF (1,739 KB) - Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination | Supplementary information

SUMO-specific protease SUSP4 positively regulates p53 by promoting Mdm2 self-ubiquitination - pp1424 - 1431

Moon Hee Lee, Sung Won Lee, Eun Joo Lee, Soo Joon Choi, Sung Soo Chung, Jae Il Lee, Joong Myung Cho, Jae Hong Seol, Sung Hee Baek, Keun Il Kim, Tomoki Chiba, Keiji Tanaka, Ok Sun Bang & Chin Ha Chung

doi:10.1038/ncb1512

First Paragraph - | Full Text - SUMO-specific protease SUSP4 positively regulates p53 by promoting Mdm2 self-ubiquitination | PDF (1,549 KB) - SUMO-specific protease SUSP4 positively regulates p53 by promoting Mdm2 self-ubiquitination | Supplementary information

The armadillo protein p0071 regulates Rho signalling during cytokinesis - pp1432 - 1440

Annika Wolf, Rene Keil, Oliver Götzl, Andrej Mun, Katrin Schwarze, Marcell Lederer, Stefan Hüttelmaier & Mechthild Hatzfeld

doi:10.1038/ncb1504

First Paragraph - | Full Text - The armadillo protein p0071 regulates Rho signalling during cytokinesis | PDF (2,199 KB) - The armadillo protein p0071 regulates Rho signalling during cytokinesis | Supplementary information

Cyclin E–Cdk2 temporally regulates centrosome assembly and establishment of polarity in Caenorhabditis elegans embryos - pp1441 - 1447

Carrie R. Cowan & Anthony A. Hyman

doi:10.1038/ncb1511

First Paragraph - | Full Text - Cyclin E–Cdk2 temporally regulates centrosome assembly and establishment of polarity in Caenorhabditis elegans embryos | PDF (1,694 KB) - Cyclin E–Cdk2 temporally regulates centrosome assembly and establishment of polarity in Caenorhabditis elegans embryos | Supplementary information

Lsh is required for meiotic chromosome synapsis and retrotransposon silencing in female germ cells - pp1448 - 1454

Rabindranath De La Fuente, Claudia Baumann, Tao Fan, Anja Schmidtmann, Ina Dobrinski & Kathrin Muegge

doi:10.1038/ncb1513

First Paragraph - | Full Text - Lsh is required for meiotic chromosome synapsis and retrotransposon silencing in female germ cells | PDF (1,958 KB) - Lsh is required for meiotic chromosome synapsis and retrotransposon silencing in female germ cells | Supplementary information