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Upgrading the BCL-2 Network

Nature Cell Biology volume 8, pages 1317–1319 (2006)Cite this article

The BCL-2 oncogene promotes cancer progression by prohibiting cell death. BCL-2-related regulators were once thought to constitute a simple, two-class system of anti-death and pro-death factors. New data delineate a multistep hierarchy of BCL-2-family protein interactions that are driven by signal-dependent pathways.

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Figure 1: The direct model for activation of BAX and BAK.
Figure 2: The hierarchy model for activation of BAX and BAK.

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Authors and Affiliations

  1. Department of Molecular Microbiology & Immunology, Johns Hopkins University School of Public Health, Baltimore, 21205, MD, USA

    Heidi L. Galonek & J. Marie Hardwick

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  1. Heidi L. Galonek
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  2. J. Marie Hardwick
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Galonek, H., Hardwick, J. Upgrading the BCL-2 Network. Nat Cell Biol 8, 1317–1319 (2006). https://doi.org/10.1038/ncb1206-1317

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