The response of some G-protein coupled receptors (GPRCs) is affected by the voltage across the membrane in which they sit. A study now shows that gating currents, similar to those of ion channels, are associated with this alteration in GPRC activity. The currents depend on structural elements of the receptor that functionally couple to G proteins.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
GPCR voltage dependence controls neuronal plasticity and behavior
Nature Communications Open Access 13 December 2021
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Jiang, Y. et al. Nature 423, 33–41 (2003).
Armstrong, C.M. & Bezanilla, F. Nature 242, 459–461 (1973).
Ben-Chaim, Y. et al. Nature 444, 106–109 (2006).
Gether, U. Endocr. Rev. 21, 90–113 (2000).
Cohen-Armon, M. & Sokolovsky, M. J. Biol. Chem. 266, 2595–2605 (1991).
Ben-Chaim, Y., Tour, O., Dascal, N., Parnas, I. & Parnas, H. J. Biol. Chem. 278, 22482–22491 (2003).
Ohana, L., Barchad, O., Parnas I. & Parnas H. J. Biol. Chem. 281, 24203–24215 (2006).
Martinez-Pinna, J., Tolhurst, G., Gurung, I.S., Vandenburg, J.I. & Mahaut-Smith, M.P. J. Physiol. 555, 61–70 (2003).
Martinez-Pinna, J. et al. J. Biol. Chem. 280, 1490–1498 (2005).
Cone, R.A. Science 155, 1128–1131 (1967).
Kenakin, T. Trends Pharmacol. Sci. 25, 186–192 (2004).
Arnis, S., Fahmy, K., Hofmann, K.P. & Sakmar, T.P. J. Biol. Chem. 269, 23879–23881 (1994).
Sheer, A. Fanelli, F., Costa, T., De Benedetti, P.G. & Cotecchia, S. EMBO J. 15, 3566–3578 (1996).
Ballesteros, J. et al. J. Biol. Chem. 273, 10445–10453 (1998).
Slutsky, I., Rashkoven, G., Parnas, H. & Parnas I. J. Neurosci. 22, 3426–3433 (2002).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Stanfield, P. Voltage sparks a GPCR. Nat Cell Biol 8, 1323–1325 (2006). https://doi.org/10.1038/ncb1206-1323
Issue Date:
DOI: https://doi.org/10.1038/ncb1206-1323
This article is cited by
-
GPCR voltage dependence controls neuronal plasticity and behavior
Nature Communications (2021)
-
Novel consequences of voltage-dependence to G-protein-coupled P2Y1receptors
British Journal of Pharmacology (2008)