Developing cell biology - pE149

doi:10.1038/35083094

Full Text - Developing cell biology | PDF (211 KB) - Developing cell biology

Morphogens: how big is the big picture? - ppE151 - E154

Peter A. Lawrence

doi:10.1038/35083096

Morphogens are in the front line just now. Here I trace how the concept of a morphogen has evolved over the past 100 years and step a little beyond what we already know.

Full Text - Morphogens: how big is the big picture? | PDF (283 KB) - Morphogens: how big is the big picture?

Straight or split: signals to transcription - ppE155 - E156

Marcel van den Heuvel

doi:10.1038/35083101

Since the discovery of substances in serum media that are able to drive cells into proliferation and/or differentiation, investigators have tried to understand how such signalling molecules can influence cells to change their behaviour. The complex nature of the responses to signals, and the equally complex signalling pathway leading to those responses, have made life difficult for the researcher. However, recent evidence obtained in genetic developmental systems indicates that a multiplicity of downstream events can be accomplished by regulation of the activity of just one transcription factor.

Full Text - Straight or split: signals to transcription | PDF (119 KB) - Straight or split: signals to transcription

The fatal detachment - ppE157 - E159

Kari Alitalo

doi:10.1038/35083104

No mutation in the fibroblast-growth-factor receptor-4 (FGFR-4) signalling pathway has so far been associated with either heritable human diseases or cancer. A new study now implicates N-CAM–FGFR-4 signalling in the regulation of tumour-cell–matrix adhesion and in the metastatis of pancreatic -cell tumours.

Full Text - The fatal detachment | PDF (592 KB) - The fatal detachment

PAR-1 helps Wnt to get rid of JNK - pE158

Valerie Depraetere

doi:10.1038/35083107

Full Text - PAR-1 helps Wnt to get rid of JNK | PDF (132 KB) - PAR-1 helps Wnt to get rid of JNK

TACCing down the spindle poles - ppE159 - E161

William E. Theurkauf

doi:10.1038/35083110

Centrosomes define the poles of mitotic spindles, but spindles that lack centrosomes mediate meiotic chromosome segregation in females. Recent studies provide new insight into anastral-spindle assembly, and indicate that a conserved protein complex may be critical to the stability of both the astral- and anastral-spindle pole.

Full Text - TACCing down the spindle poles | PDF (322 KB) - TACCing down the spindle poles

Converging on extension - pE160

Sarah Greaves

doi:10.1038/35083113

Full Text - Converging on extension | PDF (94 KB) - Converging on extension

Pathway specificity for Met signalling - ppE161 - E162

Paolo M. Comoglio

doi:10.1038/35083116

Signals generated by the tyrosine kinase receptor Met elicit a complex biological response including cell dissociation, migration, protection from apoptosis, proliferation and differentiation. Paradoxically, all these are triggered by phosphorylation of a single two-tyrosine motif in the Met receptor tail, docking multiple SH2 signal transducers. The precise amino acid sequence of the motif is an absolute requirement for fulfilling the response, showing that there is specificity in intracellular pathways.

Full Text - Pathway specificity for Met signalling | PDF (1,507 KB) - Pathway specificity for Met signalling

Human cloning and headless frogs - pE163

doi:10.1038/35083119

Full Text - Human cloning and headless frogs | PDF (145 KB) - Human cloning and headless frogs

A passion for development - pE164

doi:10.1038/35083122

Full Text - A passion for development | PDF (171 KB) - A passion for development

Powerful ideas driven by simple tools: lessons from experimental embryology - ppE165 - E167

Molly Weaver & Brigid Hogan

doi:10.1038/35083125

Abstract - Powerful ideas driven by simple tools: lessons from experimental embryology | Full Text - Powerful ideas driven by simple tools: lessons from experimental embryology | PDF (230 KB) - Powerful ideas driven by simple tools: lessons from experimental embryology

'Super glue' - ppE168 - E170

Vania Braga & Adrian J. Harwood

doi:10.1038/35083128

Abstract - 'Super glue' | Full Text - 'Super glue' | PDF (251 KB) - 'Super glue'

PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling - pp628 - 636

Tian-Qiang Sun, Bingwei Lu, Jia-Jia Feng, Christoph Reinhard, Yuh Nung Jan, Wendy J. Fantl & Lewis T. Williams

doi:10.1038/35083016

Abstract - PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling | Full Text - PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling | PDF (783 KB) - PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling | Supplementary information

Msps protein is localized to acentrosomal poles to ensure bipolarity of Drosophila meiotic spindles - pp637 - 642

C. Fiona Cullen & Hiroyuki Ohkura

doi:10.1038/35083025

Abstract - Msps protein is localized to acentrosomal poles to ensure bipolarity of : Drosophila: meiotic spindles | Full Text - Msps protein is localized to acentrosomal poles to ensure bipolarity of Drosophila meiotic spindles | PDF (2,080 KB) - Msps protein is localized to acentrosomal poles to ensure bipolarity of Drosophila meiotic spindles

Msps/XMAP215 interacts with the centrosomal protein D-TACC to regulate microtubule behaviour - pp643 - 649

Michael J. Lee, Fanni Gergely, Kim Jeffers, Sew Yeu Peak-Chew & Jordan W. Raff

doi:10.1038/35083033

Abstract - Msps/XMAP215 interacts with the centrosomal protein D-TACC to regulate microtubule behaviour | Full Text - Msps/XMAP215 interacts with the centrosomal protein D-TACC to regulate microtubule behaviour | PDF (2,261 KB) - Msps/XMAP215 interacts with the centrosomal protein D-TACC to regulate microtubule behaviour | Supplementary information

N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling - pp650 - 657

Ugo Cavallaro, Joachim Niedermeyer, Martin Fuxa & Gerhard Christofori

doi:10.1038/35083041

Abstract - N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling | Full Text - N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling | PDF (2,536 KB) - N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling | Supplementary information

SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P - pp658 - 666

Yue Xu, Heinz Hortsman, Lifong Seet, Siew Heng Wong & Wanjin Hong

doi:10.1038/35083051

Abstract - SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P | Full Text - SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P | PDF (4,648 KB) - SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P

Acetylation control of the retinoblastoma tumour-suppressor protein - pp667 - 674

Ho Man Chan, Marija Krstic-Demonacos, Linda Smith, Constantinos Demonacos & Nicholas B. La Thangue

doi:10.1038/35083062

Abstract - Acetylation control of the retinoblastoma tumour-suppressor protein | Full Text - Acetylation control of the retinoblastoma tumour-suppressor protein | PDF (492 KB) - Acetylation control of the retinoblastoma tumour-suppressor protein | Supplementary information

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow - pp683 - 686

Anna Bafico, Guizhong Liu, Abraham Yaniv, Arnona Gazit & Stuart A. Aaronson

doi:10.1038/35083081

Abstract - Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow | Full Text - Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow | PDF (265 KB) - Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

Yeast Eps15-like endocytic protein, Pan1p, activates the Arp2/3 complex - pp687 - 690

Mara C. Duncan, M. Jamie T. V. Cope, Bruce L. Goode, Beverly Wendland & David G. Drubin

doi:10.1038/35083087

Abstract - Yeast Eps15-like endocytic protein, Pan1p, activates the Arp2/3 complex | Full Text - Yeast Eps15-like endocytic protein, Pan1p, activates the Arp2/3 complex | PDF (288 KB) - Yeast Eps15-like endocytic protein, Pan1p, activates the Arp2/3 complex