The rewards of a life of commitment to science - ppE159 - E160

doi:10.1038/35023636

Full Text - The rewards of a life of commitment to science | PDF (71 KB) - The rewards of a life of commitment to science

Mdm2–SUMO1: is bigger better? - ppE161 - E163

Frauke Melchior & Ludger Hengst

doi:10.1038/35023639

Covalent modification of the oncogene product Mdm2 by the ubiquitin-related protein SUMO1 protects it from ubiquitination and enhances its E3 ligase activity towards p53 in vitro. Disappearance of SUMO-modified Mdm2, which is observed upon radiation, may thus be a prerequisite for DNA-damage-induced accumulation of p53.

Full Text - Mdm2–SUMO1: is bigger better? | PDF (91 KB) - Mdm2–SUMO1: is bigger better?

Heat-shock proteins as death determinants - ppE163 - E165

Steven Xanthoudakis & Donald W. Nicholson

doi:10.1038/35023643

The molecular pathways that mediate apoptosis are tightly regulated by a series of positive and negative signals, the balance of which determines whether or not cells commit suicide. New data from several laboratories now show that heat-shock proteins (HSPs) can influence this process through direct physical interaction with key components of the apoptotic machinery. These reports marry the survival (or death)-endowing properties of HSPs to the cell-death pathway.

Full Text - Heat-shock proteins as death determinants | PDF (102 KB) - Heat-shock proteins as death determinants

Heartfelt crosstalk: desensitization of the GIRK current - ppE165 - E167

Lily Yeh Jan & Yuh Nung Jan

doi:10.1038/35023646

Acetylcholine calms the heartbeat by activating G_i-coupled receptors and G-protein-activated inwardly rectifying potassium (GIRK) channels. It also dampens the GIRK current by reducing PIP₂ through G_q-coupled receptors. These two types of receptors seem to be engaged in an intriguingly specific form of crosstalk, which leads to desensitization of the GIRK current.

Full Text - Heartfelt crosstalk: desensitization of the GIRK current | PDF (92 KB) - Heartfelt crosstalk: desensitization of the GIRK current

cAMP takes control - ppE167 - E168

Steven M. Frisch

doi:10.1038/35023650

Although it has long been appreciated that cAMP-related signalling can control cell growth, the mechanism by which this control is exerted has remained unknown. However, new findings now show how cAMP, acting through protein kinase A (PKA), maintains cells in an anchorage-dependent state by inhibiting mitogen-activated protein kinase (MAPK) signalling through p21-activated kinases (PAKs).

Full Text - cAMP takes control | PDF (78 KB) - cAMP takes control

Opening the gates to molecular medicine - pE169

Blanche Schwappach reviews Ion Channels and Disease — Channelopathies by Frances Ashcroft

doi:10.1038/35023653

Full Text - Opening the gates to molecular medicine | PDF (75 KB) - Opening the gates to molecular medicine

An intact HDM2 RING-finger domain is required for nuclear exclusion of p53 - pp563 - 568

Scott D. Boyd, Kenneth Y. Tsai & Tyler Jacks

doi:10.1038/35023500

Abstract - | Full Text - An intact HDM2 RING-finger domain is required for nuclear exclusion of p53 | PDF (1,395 KB) - An intact HDM2 RING-finger domain is required for nuclear exclusion of p53

The MDM2 RING-finger domain is required to promote p53 nuclear export - pp569 - 573

Rory K. Geyer, Zhong K. Yu & Carl G. Maki

doi:10.1038/35023507

Abstract - | Full Text - The MDM2 RING-finger domain is required to promote p53 nuclear export | PDF (455 KB) - The MDM2 RING-finger domain is required to promote p53 nuclear export

Pyk2 and FAK regulate neurite outgrowth induced by growth factors and integrins - pp574 - 581

Inga Ivankovic-Dikic, Eva Grönroos, Andree Blaukat, Bernd-Uwe Barth & Ivan Dikic

doi:10.1038/35023515

Abstract - | Full Text - Pyk2 and FAK regulate neurite outgrowth induced by growth factors and integrins | PDF (338 KB) - Pyk2 and FAK regulate neurite outgrowth induced by growth factors and integrins

Retention of prominin in microvilli reveals distinct cholesterol-based lipid micro-domains in the apical plasma membrane - pp582 - 592

Katja Röper, Denis Corbeil & Wieland B. Huttner

doi:10.1038/35023524

Abstract - | Full Text - Retention of prominin in microvilli reveals distinct cholesterol-based lipid micro-domains in the apical plasma membrane | PDF (917 KB) - Retention of prominin in microvilli reveals distinct cholesterol-based lipid micro-domains in the apical plasma membrane | Supplementary information

Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase - pp593 - 600

Alan K. Howe & Rudolph L. Juliano

doi:10.1038/35023536

Abstract - | Full Text - Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase | PDF (325 KB) - Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase

See also: News and Views by Frisch

The DNA repair protein Rad23 is a negative regulator of multi-ubiquitin chain assembly - pp601 - 608

Tatiana G. Ortolan, Prasad Tongaonkar, David Lambertson, Li Chen, Cherylene Schauber & Kiran Madura

doi:10.1038/35023547

Abstract - | Full Text - The DNA repair protein Rad23 is a negative regulator of multi-ubiquitin chain assembly | PDF (252 KB) - The DNA repair protein Rad23 is a negative regulator of multi-ubiquitin chain assembly

The Grapes checkpoint coordinates nuclear envelope breakdown and chromosome condensation - pp609 - 615

Kristina R. Yu, Robert B. Saint & William Sullivan

doi:10.1038/35023555

Abstract - | Full Text - The Grapes checkpoint coordinates nuclear envelope breakdown and chromosome condensation | PDF (588 KB) - The Grapes checkpoint coordinates nuclear envelope breakdown and chromosome condensation

Functional localization of single active ion channels on the surface of a living cell - pp616 - 619

Yuri E. Korchev, Yuri A. Negulyaev, Christopher R.W. Edwards, Igor Vodyanoy & Max J. Lab

doi:10.1038/35023563

Abstract - | Full Text - Functional localization of single active ion channels on the surface of a living cell | PDF (393 KB) - Functional localization of single active ion channels on the surface of a living cell

Polarized localization of yeast Pbs2 depends on osmostress, the membrane protein Sho1 and Cdc42 - pp620 - 627

Vladimír Reiser, Suhal M. Salah & Gustav Ammerer

doi:10.1038/35023568

Abstract - | Full Text - Polarized localization of yeast Pbs2 depends on osmostress, the membrane protein Sho1 and Cdc42 | PDF (326 KB) - Polarized localization of yeast Pbs2 depends on osmostress, the membrane protein Sho1 and Cdc42

Neurodegenerative stimuli induce persistent ADF/cofilin–actin rods that disrupt distal neurite function - pp628 - 636

Laurie S. Minamide, Amanda M. Striegl, Judith A. Boyle, Peter J. Meberg & James R. Bamburg

doi:10.1038/35023579

Abstract - | Full Text - Neurodegenerative stimuli induce persistent ADF/cofilin–actin rods that disrupt distal neurite function | PDF (536 KB) - Neurodegenerative stimuli induce persistent ADF/cofilin–actin rods that disrupt distal neurite function

Inhibition of RhoA by p120 catenin - pp637 - 644

Panos Z. Anastasiadis, Sun Y. Moon, Molly A. Thoreson, Debbie J. Mariner, Howard C. Crawford, Yi Zheng & Albert B. Reynolds

doi:10.1038/35023588

Abstract - | Full Text - Inhibition of RhoA by p120 catenin | PDF (703 KB) - Inhibition of RhoA by p120 catenin

Hsp27 negatively regulates cell death by interacting with cytochrome c - pp645 - 652

Jean-Marie Bruey, Cécile Ducasse, Philippe Bonniaud, Luigi Ravagnan, Santos A. Susin, Chantal Diaz-Latoud, Sandeep Gurbuxani, André-Patrick Arrigo, Guido Kroemer, Eric Solary & Carmen Garrido

doi:10.1038/35023595

Abstract - | Full Text - Hsp27 negatively regulates cell death by interacting with cytochrome c | PDF (247 KB) - Hsp27 negatively regulates cell death by interacting with cytochrome c

See also: News and Views by Xanthoudakis & Nicholson

Nuclear-cytoplasmic shuttling of APC regulates -catenin subcellular localization and turnover - pp653 - 660

Beric R. Henderson

doi:10.1038/35023605

Abstract - | Full Text - Nuclear-cytoplasmic shuttling of APC regulates -catenin subcellular localization and turnover | PDF (910 KB) - Nuclear-cytoplasmic shuttling of APC regulates -catenin subcellular localization and turnover | Supplementary information

Annexation of the interchromosomal space during viral infection - pp661 - 665

Karine Monier, Juan Carlos González Armas, Susanne Etteldorf, Peter Ghazal & Kevin F. Sullivan

doi:10.1038/35023615

Abstract - | Full Text - Annexation of the interchromosomal space during viral infection | PDF (538 KB) - Annexation of the interchromosomal space during viral infection | Supplementary information

Mechanical control of cyclic AMP signalling and gene transcription through integrins - pp666 - 668

Christian J. Meyer, Francis J. Alenghat, Paul Rim, Jenny Hwai-Jen Fong, Ben Fabry & Donald E. Ingber

doi:10.1038/35023621

Abstract - | Full Text - Mechanical control of cyclic AMP signalling and gene transcription through integrins | PDF (88 KB) - Mechanical control of cyclic AMP signalling and gene transcription through integrins

Intrinsic lattice formation by the ryanodine receptor calcium-release channel - pp669 - 671

Chang Cheng Yin & F. Anthony Lai

doi:10.1038/35023625

Abstract - | Full Text - Intrinsic lattice formation by the ryanodine receptor calcium-release channel | PDF (278 KB) - Intrinsic lattice formation by the ryanodine receptor calcium-release channel

Polo-like kinase-1 is a target of the DNA damage checkpoint - pp672 - 676

Veronique A. J. Smits, Rob Klompmaker, Lionel Arnaud, Gert Rijksen, Erich A. Nigg & René H. Medema

doi:10.1038/35023629

Abstract - | Full Text - Polo-like kinase-1 is a target of the DNA damage checkpoint | PDF (187 KB) - Polo-like kinase-1 is a target of the DNA damage checkpoint

Corrections - p676

doi:10.1038/35023634

Full Text - Corrections | PDF (46 KB) - Corrections