The molecular pathways that mediate apoptosis are tightly regulated by a series of positive and negative signals, the balance of which determines whether or not cells commit suicide. New data from several laboratories now show that heat-shock proteins (HSPs) can influence this process through direct physical interaction with key components of the apoptotic machinery. These reports marry the survival (or death)-endowing properties of HSPs to the cell-death pathway.
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References
Nicholson, D. W. Cell Death Differ. 6, 1028–1042 (1999).
Cecconi, F. Cell Death Differ. 6, 1087–1098 (1999).
Saibil, H. Curr. Opin. Struct. Biol. 10, 251– 258 (2000).
Xanthoudakis, S. et al. EMBO J. 18, 2049–2056 (1999).
Samali, A., Cai, J., Zhivotovsky, B., Jones, D. P. & Orrenius, S. EMBO J. 18, 2040– 2048 (1999).
Bruey, J-M. et al. Nature Cell Biol. 2, 645– 652 (2000).
Beere, H. M. et al. Nature Cell Biol. 2, 469– 475 (2000).
Saleh, A., Srinivasula, S., Balkir, L., Robbins, P. D. & Alnemri, E. S. Nature Cell Biol. 2, 476–483 (2000).
Li, C. Y., Lee, J. S., Ko, Y. G., Kim, J. I. & Seo, J. S. J. Biol. Chem. 275, 25665– 25671 (2000).
Pandey, P. et al. EMBO J. 19, 4310–4322 (2000).
Vaughn, D. E., Rodriguez, J., Lazebnik, Y. & Joshua-Tor, L. J. Mol. Biol. 293, 439–447 (1999).
Lewis, J. et al. J. Biol. Chem. 275, 10519– 10526 (2000).
Takayama, S. et al. EMBO J. 16, 4887–4896 (1997).
Stuart, J. K. et al. J. Biol. Chem. 273, 22506– 22514 (1998).
Wang, H. G., Takayama, S., Rapp, U. R. & Reed, J. C. Proc. Natl Acad. Sci. USA 93, 7063– 7068 (1996).
Bardelli, A. et al. EMBO J. 15, 6205–6212 (1996).
Zeiner, M. & Gehring, U. Proc. Natl Acad. Sci. USA 92, 11465–11469 (1995).
Jaattela, M., Wissing, D., Kokholm, K., Kallunki, T. & Egeblad, M. EMBO J. 17, 6124– 6134 (1998).
Pandey, P. et al. Oncogene 19, 1975– 1981 (2000).
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Xanthoudakis, S., Nicholson, D. Heat-shock proteins as death determinants. Nat Cell Biol 2, E163–E165 (2000). https://doi.org/10.1038/35023643
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DOI: https://doi.org/10.1038/35023643
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