Supplements

Transcribing the genome

Vol. 461, No. 7261 pp 185–223

In this supplement

• Editorial
• Reviews

An organism's genome consists of a complex code that specifies not only the DNA sequence of genes but also how and when they are transcribed. Recent technological advances have broadened our understanding of how this genomic DNA is transcribed into RNA and how various DNA sequences regulate gene activity. This research is improving the way in which genomic information can guide research into disease.

Editorial

Transcribing the genome free access

Alex Eccleston & Magdalena Skipper

doi:10.1038/461185a

Full Text | PDF (833KB)

Reviews

Defining mechanisms that regulate RNA polymerase II transcription in vivo

Nicholas J. Fuda, M. Behfar Ardehali & John T. Lis

doi:10.1038/nature08449

Abstract | Full Text | PDF (2,417KB)

The logic of chromatin architecture and remodelling at promoters

Bradley R. Cairns

doi:10.1038/nature08450

Abstract | Full Text | PDF (1,354KB)

Genomic views of distant-acting enhancers

Axel Visel, Edward M. Rubin & Len A. Pennacchio

doi:10.1038/nature08451

Abstract | Full Text | PDF (1,993KB)

Implications of chimaeric non-co-linear transcripts

Thomas R. Gingeras

doi:10.1038/nature08452

Abstract | Full Text | PDF (1,618KB)

Chromosome crosstalk in three dimensions

Anita Göndör & Rolf Ohlsson

doi:10.1038/nature08453

Abstract | Full Text | PDF (2,340KB)

Molecular networks as sensors and drivers of common human diseases

Eric E. Schadt

doi:10.1038/nature08454

Abstract | Full Text | PDF (3,542KB)