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Nature Insight: Epigenetics

Vol. 447, No. 7143 pp 396-440

Epigenetics cover

Genetic mechanisms alone cannot explain how some cellular traits are propagated. Rapid advances in the field of epigenetics are now revealing a molecular basis for how heritable information other than DNA sequence can influence gene function. These advances also add to our understanding of transcriptional regulation, nuclear organization, development and disease.

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Editorial

Epigenetics

Alex Eccleston, Natalie DeWitt, Chris Gunter, Barbara Marte & Deepa Nath

doi:10.1038/447395a

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Introduction

Perceptions of epigenetics

Adrian Bird

doi:10.1038/nature05913


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Reviews

Transcription and RNA interference in the formation of heterochromatin

Shiv I. S. Grewal & Sarah C. R. Elgin

doi:10.1038/nature05914


The complex language of chromatin regulation during transcription

Shelley L. Berger

doi:10.1038/nature05915


Nuclear organization of the genome and the potential for gene regulation

Peter Fraser & Wendy Bickmore

doi:10.1038/nature05916


Epigenetic inheritance in plants

Ian R. Henderson & Steven E. Jacobsen

doi:10.1038/nature05917


Stability and flexibility of epigenetic gene regulation in mammalian development

Wolf Reik

doi:10.1038/nature05918


Phenotypic plasticity and the epigenetics of human disease

Andrew P. Feinberg

doi:10.1038/nature05919