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Nature 447, 433-440 (24 May 2007) | doi:10.1038/nature05919; Published online 23 May 2007
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Gastrointestinal Pathologist
- Brigham and Women's Hospital
- Boston, MA
Organic Chemistry
- Praj Matrix - Praj Industries Ltd
- Pune, Maharashtra Pune-411021 India
Review Article Phenotypic plasticity and the epigenetics of human disease
Andrew P. Feinberg1
Abstract
It is becoming clear that epigenetic changes are involved in human disease as well as during normal development. A unifying theme of disease epigenetics is defects in phenotypic plasticity — cells' ability to change their behaviour in response to internal or external environmental cues. This model proposes that hereditary disorders of the epigenetic apparatus lead to developmental defects, that cancer epigenetics involves disruption of the stem-cell programme, and that common diseases with late-onset phenotypes involve interactions between the epigenome, the genome and the environment. Increased understanding of epigenetic-disease mechanisms could lead to disease-risk stratification for targeted intervention and to targeted therapies.
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