WEB FOCUS
Marsupial genomics
In this focus
Marsupials split off from the main mammalian lineage millions of years ago, and have been studied by biologists for years to discover what they can tell us about ancient mammals, particularly the evolution of mammalian sex chromosomes. Plus they are cute! The first marsupial genome has been sequenced and analysed from a tiny opossum named Monodelphis domestica. This Nature web focus presents the original research, and an archive of marsupial genetics and genomics.
Image: Larry Wadsworth, Media Resources, Texas A&M University.
Current Research
ARTICLE
Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences Free access
Tarjei S. Mikkelsen et al.
Nature 447, 167—177 (10 May 2007) doi:10.1038/nature05805
Abstract | Full Text | PDF | Supplementary Information
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Links
- Opossum Genome, Broad Institute
- M. domestica genome browser at The Walter and Eliza Hall Institute
- Genome sequencing proposal and resources at NHGRI
Related papers in Genome Research
Evolutionary dynamics of transposable elements in the short-tailed opossum Monodelphis domestica
Gentles et al.
Characterization of the opossum immune genome provides insights into the evolution of the mammalian immune system
Belov et al.
An analysis of the gene complement of a marsupial, Monodelphis domestica: Evolution of lineage-specific genes and giant chromosomes
Goodstadt et al.
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ARCHIVE
LETTER
Retroviral invasion of the koala genome
Rachael E. Tarlinton, Joanne Meers & Paul R. Young
Nature 442, 79—81 (6 July 2006) doi:10.1038/nature04841
LETTER
Marsupial Y chromosome encodes a homologue of the mouse Y-linked candidate spermatogenesis gene Ube1y
Michael J. Mitchell, Diane R. Woods, Steven A. Wilcox, Jennifer A. Marshall Graves & Colin E. Bishop
Nature 359, 528—531 (8 Oct 1992) doi:10.1038/359528a0
LETTER
Evolution of sex determination and the Y chromosome: SRY-related sequences in marsupials
Jamie W. Foster et al.
Nature 359, 531—533 (8 Oct 1992) doi:10.1038/359531a0
LETTER
Sequences homologous to ZFY, a candidate human sex-determining gene, are autosomal in marsupials
Andrew H. Sinclair et al.
Nature 336, 780—783 (29 Dec 1988) doi:10.1038/336780a0
CORRESPONDENCE
The candidate spermatogenesis gene RBMY has a homologue on the human X chromosome
Margaret L. Delbridge, Patricia A. Lingenfelter, Christine M. Disteche & Jennifer A. Marshall Graves
Nature Genetics 22, 223—224 (1 Jul 1999) doi:10.1038/10279
ONCOGENOMICS
Marsupial BRCA1: conserved regions in mammals and the potential effect of missense changes
Christina J. Ramirez, Melissa A. Fleming, John D. Potter, Gary K. Ostrander & Elaine A. Ostrander
Oncogene 23, 1780—1788 (4 Mar 2004) doi:10.1038/sj.onc.1207292