DNA metabolism

In this focus

The genome is the fundamental entity of a cell. Many processes are therefore directed at ensuring its faithful duplication and at repairing endogenous and exogenous damage to it. Intimate links between these two facets of DNA metabolism have been increasingly recognized. Here we highlight Nature's most recent papers on replication and repair.


Current research articles

Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA

Banerjee A., Yang W., Karplus M. & Verdine G. L.

Nature 434, 612-618 (31 March 2005) doi:10.1038/nature03458

CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

Esashi F. et al.

Nature 434, 598-604 (31 March 2005) doi:10.1038/nature03404

Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1

El-Khamisy S. F. et al.

Nature 434, 108-113 (3 March 2005) doi:10.1038/nature03314

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

Falck J., Coates J. & Jackson S. P.

Nature 434, 605-611 (2 March 2005) doi:10.1038/nature03442

The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction

Yang H. et al.

Nature 433, 653-657 (10 February 2005) doi:10.1038/nature03234


Current news & views

Structural biology: DNA search and rescue

David S. S.

Nature 434, 569 (31 March 2005) doi:10.1038/434569a

Cancer: Catalyst of a catalyst

Kowalczykowski S. C.

Nature 433, 591-592 (10 February 2005) doi:10.1038/433591a


Archive research articles

Human DNA ligase I completely encircles and partially unwinds nicked DNA

Pascal J. M. et al.

Nature 432, 473-478 (25 November 2004) doi:10.1038/nature03082

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

Huyen Y. et al.

Nature 432, 406-411 (18 November 2004) doi:10.1038/nature03114

Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaks

Singleton M. R. et al.

Nature 432, 187-193 (11 November 2004) doi:10.1038/nature02988

Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control

Mimura S. et al.

Nature 431, 1118-1123 (28 October 2004) doi:10.1038/nature03024

DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1

Ira G. et al.

Nature 431, 1011-1017 (21 October 2004) doi:10.1038/nature02964

Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase

Nagao K. et al.

Nature 431, 217-221 (09 September 2004) doi:10.1038/nature02908

Separase-mediated cleavage of cohesin at interphase is required for DNA repair

Nagao K. et al.

Nature 430, 1044-1048 (26 August 2004) doi:10.1038/nature02803

Structural basis for inhibition of the replication licensing factor Cdt1 by geminin

Lee C. et al.

Nature 430, 913-917 (19 August 2004) doi:10.1038/nature02813

Replication by human DNA polymerase-ι occurs by Hoogsteen base-pairing

Nair D. T. et al.

Nature 430, 377-380 (15 July 2004) doi:10.1038/nature02692

Chromatin regulates origin activity in Drosophila follicle cells

Aggarwal B. D. & Calvi B. R.

Nature 430, 372-376 (15 July 2004) doi:10.1038/nature02694

Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex

Bowman G. D. et al.

Nature 429, 724-730 (17 June 2004) doi:10.1038/nature02585

Human meiotic recombinase Dmc1 promotes ATP-dependent homologous DNA strand exchange

Sehorn M. G. et al.

Nature 429, 433-437 (27 May 2004) doi:10.1038/nature02563

Preferential cis-syn thymine dimer bypass by DNA polymerase occurs with biased fidelity

McCulloch S. D. et al.

Nature 428, 97-100 (4 March 2004) doi:10.1038/nature02352

Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase

Fromme J. C. et al.

Nature 427, 652-656 (12 February 2004) doi:10.1038/nature02306


Archive news & views articles

Cell biology: Holding sisters for repair

Hirano T.

Nature 433, 467-468 (3 February 2005) doi:10.1038/433467a

DNA repair: Big engine finds small breaks

Pyle A. M.

Nature 432, 157-158 (11 November 2004) doi:10.1038/432157a

Molecular biology: The loader of the rings

Trakselis M. A. & Bell S. D.

Nature 429, 708-709 (17 June 2004) doi:10.1038/429708a

Molecular biology: Ensuring error-free DNA repair

Lindahl T.

Nature 427, 598 (12 February 2004) doi:10.1038/427598a

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