WEB FOCUS
DNA metabolism
In this focus
- Current research articles
- Current news & views articles
- Archive research articles
- Archive news & views articles
The genome is the fundamental entity of a cell. Many processes are therefore directed at ensuring its faithful duplication and at repairing endogenous and exogenous damage to it. Intimate links between these two facets of DNA metabolism have been increasingly recognized. Here we highlight Nature's most recent papers on replication and repair.
Current research articles
Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA
Banerjee A., Yang W., Karplus M. & Verdine G. L.
Nature 434, 612-618 (31 March 2005) doi:10.1038/nature03458
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair
Esashi F. et al.
Nature 434, 598-604 (31 March 2005) doi:10.1038/nature03404
Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1
El-Khamisy S. F. et al.
Nature 434, 108-113 (3 March 2005) doi:10.1038/nature03314
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
Falck J., Coates J. & Jackson S. P.
Nature 434, 605-611 (2 March 2005) doi:10.1038/nature03442
The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction
Yang H. et al.
Nature 433, 653-657 (10 February 2005) doi:10.1038/nature03234
Top of pageCurrent news & views
Structural biology: DNA search and rescue
David S. S.
Nature 434, 569 (31 March 2005) doi:10.1038/434569a
Cancer: Catalyst of a catalyst
Kowalczykowski S. C.
Nature 433, 591-592 (10 February 2005) doi:10.1038/433591a
Top of pageArchive research articles
Human DNA ligase I completely encircles and partially unwinds nicked DNA
Pascal J. M. et al.
Nature 432, 473-478 (25 November 2004) doi:10.1038/nature03082
Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks
Huyen Y. et al.
Nature 432, 406-411 (18 November 2004) doi:10.1038/nature03114
Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaks
Singleton M. R. et al.
Nature 432, 187-193 (11 November 2004) doi:10.1038/nature02988
Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control
Mimura S. et al.
Nature 431, 1118-1123 (28 October 2004) doi:10.1038/nature03024
DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1
Ira G. et al.
Nature 431, 1011-1017 (21 October 2004) doi:10.1038/nature02964
Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase
Nagao K. et al.
Nature 431, 217-221 (09 September 2004) doi:10.1038/nature02908
Separase-mediated cleavage of cohesin at interphase is required for DNA repair
Nagao K. et al.
Nature 430, 1044-1048 (26 August 2004) doi:10.1038/nature02803
Structural basis for inhibition of the replication licensing factor Cdt1 by geminin
Lee C. et al.
Nature 430, 913-917 (19 August 2004) doi:10.1038/nature02813
Replication by human DNA polymerase-ι occurs by Hoogsteen base-pairing
Nair D. T. et al.
Nature 430, 377-380 (15 July 2004) doi:10.1038/nature02692
Chromatin regulates origin activity in Drosophila follicle cells
Aggarwal B. D. & Calvi B. R.
Nature 430, 372-376 (15 July 2004) doi:10.1038/nature02694
Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex
Bowman G. D. et al.
Nature 429, 724-730 (17 June 2004) doi:10.1038/nature02585
Human meiotic recombinase Dmc1 promotes ATP-dependent homologous DNA strand exchange
Sehorn M. G. et al.
Nature 429, 433-437 (27 May 2004) doi:10.1038/nature02563
Preferential cis-syn thymine dimer bypass by DNA polymerase occurs with biased fidelity
McCulloch S. D. et al.
Nature 428, 97-100 (4 March 2004) doi:10.1038/nature02352
Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase
Fromme J. C. et al.
Nature 427, 652-656 (12 February 2004) doi:10.1038/nature02306
Top of pageArchive news & views articles
Cell biology: Holding sisters for repair
Hirano T.
Nature 433, 467-468 (3 February 2005) doi:10.1038/433467a
DNA repair: Big engine finds small breaks
Pyle A. M.
Nature 432, 157-158 (11 November 2004) doi:10.1038/432157a
Molecular biology: The loader of the rings
Trakselis M. A. & Bell S. D.
Nature 429, 708-709 (17 June 2004) doi:10.1038/429708a
Molecular biology: Ensuring error-free DNA repair
Lindahl T.
Nature 427, 598 (12 February 2004) doi:10.1038/427598a
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