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Molecular biology

The loader of the rings

Among the numerous molecular machines involved in the process of DNA replication are the ring-shaped sliding clamp and the clamp loader. Intriguing structural details of their interaction are now revealed.

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Figure 1: Clamping down on DNA.

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Trakselis, M., Bell, S. The loader of the rings. Nature 429, 708–709 (2004). https://doi.org/10.1038/429708a

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