TABLE OF CONTENTS
Volume 18, Issue 4 (April 2004)
Editorial
The German competence network 'Acute and chronic leukemias' FREE
R Hehlmann, U Berger, C Aul, Th Büchner, H Döhner, G Ehninger, A Ganser, N Gökbuget, D Hoelzer, K Überla, W Gassmann, W D Ludwig, H Rieder, M Kneba, A Hochhaus, A Reiter, W Hiddemann, O G Ottmann, U Germing, K Adelhard, M Dugas, P Dirschedl, D Messerer, A Böhme, E Harrison-Neu, M Griesshammer, J Kienast, H J Kolb, A D Ho, M Hallek, A Neubauer, B Schlegelberger, D Niederwieser, G Heil, T Müller and J Hasford
Leukemia 18: 665-669; doi:10.1038/sj.leu.2403317
Original Manuscripts
Incidence and prognostic value of respiratory events in acute leukemia FREE
D Chaoui, O Legrand, N Roche, M Cornet, A Lefebvre, R Peffault de Latour, L Sanhes, G Huchon, J-P Marie and A Rabbat
Leukemia 18: 670-675; advance online publication, February 5, 2004; doi:10.1038/sj.leu.2403270
Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia FREE
C Imai, K Mihara, M Andreansky, I C Nicholson, C-H Pui, T L Geiger and D Campana
Leukemia 18: 676-684; advance online publication, February 12, 2004; doi:10.1038/sj.leu.2403302
RAS oncogene mutations and outcome of therapy for childhood acute lymphoblastic leukemia FREE
J P Perentesis, S Bhatia, E Boyle, Y Shao, X Ou Shu, M Steinbuch, H N Sather, P Gaynon, W Kiffmeyer, J Envall-Fox and L L Robison
Leukemia 18: 685-692; advance online publication, February 26, 2004; doi:10.1038/sj.leu.2403272
Secondary cytogenetic aberrations in childhood Philadelphia chromosome positive acute lymphoblastic leukemia are nonrandom and may be associated with outcome FREE
N A Heerema, J Harbott, S Galimberti, B M Camitta, P S Gaynon, G Janka-Schaub, W Kamps, G Basso, C-H Pui, M Schrappe, M-F Auclerc, A J Carroll, V Conter, C J Harrison, J Pullen, S C Raimondi, S Richards, H Riehm, H N Sather, J J Shuster, L B Silverman, M G Valsecchi and M Aricò for the Acute Lymphoblastic Leukemia Study Groups: ALL-BFM and CoALL (Germany), AIEOP (Italy), DCLSG (Netherlands), FRALLE (France), CCG, DFCI, POG and St Jude (USA), and UKALL (UK)
Leukemia 18: 693-702; doi:10.1038/sj.leu.2403324
CD99 expression in T-lineage ALL: implications for flow cytometric detection of minimal residual disease FREE
M N Dworzak, G Fröschl, D Printz, L De Zen, G Gaipa, R Ratei, G Basso, A Biondi, W-D Ludwig and H Gadner on behalf of the I-BFM-ALL-FCM-MRD-Study Group
Leukemia 18: 703-708; advance online publication, February 12, 2004; doi:10.1038/sj.leu.2403303
Rearranged T-cell receptor beta genes represent powerful targets for quantification of minimal residual disease in childhood and adult T-cell acute lymphoblastic leukemia FREE
M Brüggemann, V H J van der Velden, T Raff, J Droese, M Ritgen, C Pott, A J Wijkhuijs, N Gökbuget, D Hoelzer, E R van Wering, J J M van Dongen and M Kneba
Leukemia 18: 709-719; advance online publication, February 12, 2004; doi:10.1038/sj.leu.2403263
Expression of the p14ARF tumor suppressor predicts survival in acute myeloid leukemia FREE
C Müller-Tidow, S K Metzelder, H Buerger, J Packeisen, A Ganser, G Heil, K Kügler, G Adigüzel, J Schwäble, B Steffen, W-D Ludwig, A Heinecke, T Büchner, W E Berdel and H Serve
Leukemia 18: 720-726; advance online publication, February 19, 2004; doi:10.1038/sj.leu.2403296
p210BCR/ABL-induced alteration of pre-mRNA splicing in primary human CD34+ hematopoietic progenitor cells FREE
S Salesse, S J Dylla and C M Verfaillie
Leukemia 18: 727-733; advance online publication, February 12, 2004; doi:10.1038/sj.leu.2403310
Clinical and molecular features of FIP1L1-PDFGRA (+) chronic eosinophilic leukemias FREE
P Vandenberghe, I Wlodarska, L Michaux, P Zachée, M Boogaerts, D Vanstraelen, M-C Herregods, A Van Hoof, D Selleslag, F Roufosse, M Maerevoet, G Verhoef, J Cools, D G Gilliland, A Hagemeijer and P Marynen
Leukemia 18: 734-742; advance online publication, February 19, 2004; doi:10.1038/sj.leu.2403313
Bcl-6 mutation status provides clinically valuable information in early-stage B-cell chronic lymphocytic leukemia FREE
E Sarsotti, I Marugan, I Benet, M J Terol, D Sanchez-Izquierdo, M Tormo, F Rubio-Moscardo, J A Martinez-Climent and J García-Conde
Leukemia 18: 743-746; advance online publication, February 12, 2004; doi:10.1038/sj.leu.2403304
Cyclin-dependent kinase inhibitor Roscovitine induces apoptosis in chronic lymphocytic leukemia cells FREE
I N Hahntow, F Schneller, M Oelsner, K Weick, I Ringshausen, F Fend, C Peschel and T Decker
Leukemia 18: 747-755; advance online publication, February 19, 2004; doi:10.1038/sj.leu.2403295
High expression of activation-induced cytidine deaminase (AID) mRNA is associated with unmutated IGVH gene status and unfavourable cytogenetic aberrations in patients with chronic lymphocytic leukaemia FREE
D Heintel, E Kroemer, D Kienle, I Schwarzinger, A Glei
, J Schwarzmeier, R Marculescu, T Le, C Mannhalter, A Gaiger, S Stilgenbauer, H Döhner, C Fonatsch, U Jäger and the German CLL Study Group
Leukemia 18: 756-762; advance online publication, February 12, 2004; doi:10.1038/sj.leu.2403294
Aggressive natural killer-cell leukemia revisited: large granular lymphocyte leukemia of cytotoxic NK cells FREE
R Suzuki, J Suzumiya, S Nakamura, S Aoki, A Notoya, S Ozaki, H Gondo, N Hino, H Mori, H Sugimori, K Kawa and K Oshimi for the NK-cell Tumor Study Group
Leukemia 18: 763-770; advance online publication, February 12, 2004; doi:10.1038/sj.leu.2403262
The raft marker GM1 identifies functional subsets of granular lymphocytes in patients with CD3+ lymphoproliferative disease of granular lymphocytes FREE
R Zambello, A Cabrelle, L Trentin, C Agostini, G Semenzato and A Viola
Leukemia 18: 771-776; doi:10.1038/sj.leu.2403292
Expression of constitutively active Notch4 (Int-3) modulates myeloid proliferation and differentiation and promotes expansion of hematopoietic progenitors FREE
Q Ye, J-H Shieh, G Morrone and M A S Moore
Leukemia 18: 777-787; advance online publication, February 12, 2004; doi:10.1038/sj.leu.2403291
Membrane-bound Delta-4 Notch ligand reduces the proliferative activity of primitive human hematopoietic CD34+CD38low cells while maintaining their LTC-IC potential FREE
E Lauret, C Catelain, M Titeux, S Poirault, J S Dando, M Dorsch, J-L Villeval, A Groseil, W Vainchenker, F Sainteny and A Bennaceur-Griscelli
Leukemia 18: 788-797; advance online publication, February 26, 2004; doi:10.1038/sj.leu.2403288
Direct cloning of leukemia-reactive T cells from patients treated with donor lymphocyte infusion shows a relative dominance of hematopoiesis-restricted minor histocompatibility antigen HA-1 and HA-2 specific T cells FREE
F M Kloosterboer, S A P van Luxemburg-Heijs, RA van Soest, A M Barbui, HM van Egmond, M P W Strijbosch, M G D Kester, W A F Marijt, E Goulmy, R Willemze and J H F Falkenburg
Leukemia 18: 798-808; advance online publication, February 19, 2004; doi:10.1038/sj.leu.2403297
Decision-making and quality of life in older adults with acute myeloid leukemia or advanced myelodysplastic syndrome FREE
M A Sekeres, R M Stone, D Zahrieh, D Neuberg, V Morrison, D J De Angelo, I Galinsky and S J Lee
Leukemia 18: 809-816; advance online publication, February 5, 2004; doi:10.1038/sj.leu.2403289
Gene transfer of pro-IL-18 and IL-1
converting enzyme cDNA induces potent antitumor effects in L1210 cells FREE
B Zhang, K-F Wu, Y-M Lin, X-T Ma, Q Rao, G-G Zheng, Z-Y Cao, G Li and Y-H Song
Leukemia 18: 817-825; advance online publication, February 26, 2004; doi:10.1038/sj.leu.2403320
Activation-induced cytidine deaminase expression in follicular lymphoma: association between AID expression and ongoing mutation in FL FREE
M S Hardianti, E Tatsumi, M Syampurnawati, K Furuta, K Saigo, Y Nakamachi, S Kumagai, H Ohno, S Tanabe, M Uchida and N Yasuda
Leukemia 18: 826-831; advance online publication, February 26, 2004; doi:10.1038/sj.leu.2403323
Defective class II transactivator expression in a B lymphoma cell line FREE
T Prod'homme, B Drénou, C De Ruyffelaere, G Barbieri, W Wiszniewski, C Bastard, D Charron and C Alcaide-Loridan
Leukemia 18: 832-840; advance online publication, February 19, 2004; doi:10.1038/sj.leu.2403315
Identification of genes whose expression patterns differ in benign lymphoid tissue and follicular, mantle cell, and small lymphocytic lymphoma FREE
S C Schmechel, R J LeVasseur, K H-J Yang, K M Koehler, S J Kussick and D E Sabath
Leukemia 18: 841-855; advance online publication, February 12, 2004; doi:10.1038/sj.leu.2403293
The oral combination of thalidomide, cyclophosphamide and dexamethasone (ThaCyDex) is effective in relapsed/refractory multiple myeloma FREE
R García-Sanz, J R González-Porras, J M Hernández, M Polo-Zarzuela, A Sureda, C Barrenetxea, L Palomera, R López, C Grande-García, A Alegre, M Vargas-Pabón, O N Gutiérrez, J A Rodríguez and J F San Miguel
Leukemia 18: 856-863; advance online publication, February 19, 2004; doi:10.1038/sj.leu.2403322
Biotechnical Methods Section (BTS)
Detection of ABL kinase domain mutations with denaturing high-performance liquid chromatography FREE
M W N Deininger, L McGreevey, S Willis, T M Bainbridge, B J Druker and M C Heinrich
Leukemia 18: 864-871; advance online publication, February 19, 2004; doi:10.1038/sj.leu.2403307
Correspondence
Novel technique to facilitate the rapid identification of CLL patients utilising the VH3–21 gene FREE
Z A Davis, R E Ibbotson, C M Wiseman and D G Oscier
Leukemia 18: 872; advance online publication, February 12, 2004; doi:10.1038/sj.leu.2403290
Integrins regulate survival of pre-B-ALL cells through differential IAP and caspase-7 ubiquitination and degradation FREE
A L Astier, M Svoboda, E Hinds, R de Beaumont, O Munoz and A S Freedman
Leukemia 18: 873-875; advance online publication, February 19, 2004; doi:10.1038/sj.leu.2403298
Minimal residual disease cells in AML patients have an apoptosis-sensitive protein profile FREE
A van Stijn, A Kok, M A van Stalborch, M A van der Pol, N Feller, A H Westra, G J Ossenkoppele and G J Schuurhuis
Leukemia 18: 875-877; advance online publication, February 5, 2004; doi:10.1038/sj.leu.2403299
A case of refractory anemia with 17p- syndrome following azathioprine treatment for heart transplantation FREE
S Depil, P Lepelley, V Soenen, C Preudhomme, J L Lai, F Broly and B Quesnel
Leukemia 18: 878; advance online publication, February 12, 2004; doi:10.1038/sj.leu.2403305
Prophylactic intrathecal chemotherapy in acute promyelocytic leukemia (APL) FREE
F Ravandi
Leukemia 18: 879-880; advance online publication, February 12, 2004; doi:10.1038/sj.leu.2403306
Abnormal mRNA expression of ASPP members in leukemia cell lines FREE
Z-J Liu, Y Zhang, X-B Zhang and X Yang
Leukemia 18: 880; advance online publication, February 19, 2004; doi:10.1038/sj.leu.2403300
No evidence for core-binding factor CBF as a leukemia predisposing factor in chromosome 16q22-linked familial AML FREE
R Escher, F Hagos, J Michaud, L Sveen, M Horwitz, O I Olopade and H S Scott
Leukemia 18: 881; advance online publication, February 12, 2004; doi:10.1038/sj.leu.2403308
Revisiting the definition of somatic mutational status in B-cell tumors: does 98% homology mean that a V H-gene is unmutated? FREE
F Forconi, S S Sahota, F Lauria and F K Stevenson
Leukemia 18: 882-883; advance online publication, February 19, 2004; doi:10.1038/sj.leu.2403312
Differential stability of control gene and fusion gene transcripts over time may hamper accurate quantification of minimal residual disease – a study within the Europe Against Cancer Program FREE
V H J van der Velden, N Boeckx, M Gonzalez, M Malec, G Barbany, T Lion, E Gottardi, N Pallisgaard, E Beillard, W C J Hop, P G Hoogeveen, J Gabert and J J M van Dongen on behalf of the Europe Against Cancer Program
Leukemia 18: 884-886; advance online publication, February 12, 2004; doi:10.1038/sj.leu.2403309
Imatinib mesylate associated with delayed hematopoietic recovery after concomitant chemotherapy FREE
M Chand, M Thakuri and Y-K Keung
Leukemia 18: 886-887; advance online publication, February 12, 2004; doi:10.1038/sj.leu.2403311
Response to Chand et al FREE
C Gambacorti-Passerini
Leukemia 18: 887; advance online publication, February 12, 2004; doi:10.1038/sj.leu.2403314
Erythroleukaemia and RAEB-t: a same disease? FREE
S Park, F Picard, M Guesnu, K Maloum, V Leblond and F Dreyfus
Leukemia 18: 888-890; advance online publication, February 19, 2004; doi:10.1038/sj.leu.2403316
The higher expression of 
and isoforms of the human glucocorticoid receptor in leukemic B-progenitors compared to normal CD10+ BM cells does not correlate with methylprednisolone-induced apoptosis FREE
L M M Albuquerque, A B Garcia, J O Mengel, R P Falcão, M de Castro and E M Rego
Leukemia 18: 890-892; advance online publication, February 19, 2004; doi:10.1038/sj.leu.2403318
