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Peroxisome proliferator-activated receptor α (PPARα) activation advances locomotor activity and feeding daily rhythms in mice

International Journal of Obesity volume 36, pages 1131–1134 (2012)Cite this article

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Abstract

Peroxisome proliferator-activated receptors (PPARs) are key mediators of energy homeostasis, and lipid and glucose metabolism that exhibit circadian expression. PPAR activating drugs are used clinically as lipid and glucose-lowering drugs. We evaluated the effect of long-term (11 weeks) PPARα and PPARγ activation using bezafibrate and rosiglitazone, respectively, on metabolism, locomotor activity and feeding rhythms of non-obese mice. We found that bezafibrate, but not rosiglitazone, led to no weight gain and a slight weight loss with reduced epididymal fat pads. Although rosiglitazone had a minor effect on 24-h food intake rhythm, bezafibrate treatment was accompanied by increased amplitude and an advanced acrophase of the 24-h feeding rhythm. Similarly, unlike rosiglitazone, bezafibrate treatment was accompanied by a significantly advanced acrophase of locomotor activity rhythm under constant darkness conditions. As disrupted circadian rhythms lead to obesity, PPARα activation can serve as a clinical target for the modulation of both circadian rhythms and metabolism.

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Authors and Affiliations

  1. Institute of Biochemistry, Food Science and Nutrition, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel

    R Gutman, M Barnea, L Haviv, N Chapnik & O Froy

  2. Department of Nutritional Sciences, Faculty of Sciences and Technology, Tel-Hai College, Upper Galilee, Israel

    R Gutman

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  1. R Gutman
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  2. M Barnea
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  3. L Haviv
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  4. N Chapnik
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  5. O Froy
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Correspondence to O Froy.

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Gutman, R., Barnea, M., Haviv, L. et al. Peroxisome proliferator-activated receptor α (PPARα) activation advances locomotor activity and feeding daily rhythms in mice. Int J Obes 36, 1131–1134 (2012). https://doi.org/10.1038/ijo.2011.215

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  • DOI: https://doi.org/10.1038/ijo.2011.215

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