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Unfolding new roles for XBP1 in immunity

Nature Immunology volume 11, pages 365–367 (2010)Cite this article

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A critical aspect of innate immune function is the coordinated regulation of inflammatory gene expression. Now an unexpected discovery shows that certain signaling components of the unfolded protein response are required for optimal gene induction by Toll-like receptors.

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Figure 1: Selective activation of UPR sensors after TLR stimulation.

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Authors and Affiliations

  1. Alex Engel and Gregory M. Barton are in the Division of Immunology & Pathogenesis, Department of Molecular & Cell Biology, University of California, Berkeley, California, USA.,

    Alex Engel & Gregory M Barton

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  1. Alex Engel
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  2. Gregory M Barton
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Correspondence to Gregory M Barton.

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Engel, A., Barton, G. Unfolding new roles for XBP1 in immunity. Nat Immunol 11, 365–367 (2010). https://doi.org/10.1038/ni0510-365

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