Innate immunity

Definition

Innate immunity is an immunological subsystem that comprises the cells and mechanisms that provide the first line of defence from infection in a non-specific manner. Innate immune responses are rapid and independent of antigen. Innate immune systems are found in all classes of plants and animals.

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Latest Research and Reviews

  • Research |

    Wu et al. find that tumour hypoxic conditions increase miR25/93 levels, which via targeting Ncoa3 downregulate the expression of the innate immune regulator cGAS, thus allowing escape of the anti-tumour immune response.

    • Min-Zu Wu
    • , Wei-Chung Cheng
    • , Su-Feng Chen
    • , Shin Nieh
    • , Carolyn O’Connor
    • , Chia-Lin Liu
    • , Wen-Wei Tsai
    • , Cheng-Jang Wu
    • , Lorena Martin
    • , Yaoh-Shiang Lin
    • , Kou-Juey Wu
    • , Li-Fan Lu
    •  & Juan Carlos Izpisua Belmonte
  • Research |

    A molecular mechanism for the sensitive detection of long and U-turn DNA by cyclic GMP–AMP synthase (cGAS) both in vitro and in human cells.

    • Liudmila Andreeva
    • , Björn Hiller
    • , Dirk Kostrewa
    • , Charlotte Lässig
    • , Carina C. de Oliveira Mann
    • , David Jan Drexler
    • , Andreas Maiser
    • , Moritz Gaidt
    • , Heinrich Leonhardt
    • , Veit Hornung
    •  & Karl-Peter Hopfner
    Nature 549, 394–398
  • Research |

    TRIM23 is identified as an essential regulator of virus-induced autophagy that mediates restriction to several RNA and DNA viruses. K27-mediated ubiquitylation activates TRIM23 GTPase activity, triggering its relocalization and selective autophagy.

    • Konstantin M. J. Sparrer
    • , Sebastian Gableske
    • , Matthew A. Zurenski
    • , Zachary M. Parker
    • , Florian Full
    • , Gavin J. Baumgart
    • , Jiro Kato
    • , Gustavo Pacheco-Rodriguez
    • , Chengyu Liang
    • , Owen Pornillos
    • , Joel Moss
    • , Martha Vaughan
    •  & Michaela U. Gack
  • Research | | open

    The cGAS/STING signalling pathway is responsible for sensing intracellular DNA and activating downstream inflammatory genes. Here the authors show mouse primary T cells and T leukaemia are hyperresponsive to STING agonist, and this strong STING signalling is associated with apoptosis induction.

    • Muhammet F. Gulen
    • , Ute Koch
    • , Simone M. Haag
    • , Fabian Schuler
    • , Lionel Apetoh
    • , Andreas Villunger
    • , Freddy Radtke
    •  & Andrea Ablasser

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