FOCUS
NF-κB SIGNALING
- Special issue:
- January 2011 Volume 21, No 1
The NF-κB pathway plays an important role in regulating diverse biological processes, including the immune response, inflammation, cell growth and survival, and development. Deregulation of the NF-κB pathway leads to diseases such as autoimmunity and cancer. The January 2011 special issue on NF-κB signaling brings our understanding of this important pathway up-to-date, focusing on the NF-κB signaling mechanisms and their role in physiology and diseases. The accompanying web focus presents links to related articles from across Nature Publishing Group to provide more background information about the pathway.
Review
NF-κB in immunobiology FREE
Matthew S Hayden and Sankar Ghosh
Cell Res 21: 223-244; advance online publication, January 18, 2011; doi:10.1038/cr.2011.13
Articles
Dishevelled interacts with p65 and acts as a repressor of NF-κB-mediated transcription FREE
Ning Deng, Yanger Ye, Wei Wang and Lin Li
Cell Res 20: 1117-1127; advance online publication, July 13, 2010; doi:10.1038/cr.2010.108
Chemical probing reveals insights into the signaling mechanism of inflammasome activation FREE
Yi-Nan Gong, Xiaoming Wang, Jiayi Wang, Zhenxiao Yang, Shan Li, Jieling Yang, Liping Liu, Xiaoguang Lei and Feng Shao
Cell Res 20: 1289-1305; advance online publication, September 21, 2010; doi:10.1038/cr.2010.135
MicroRNAs modulate the noncanonical transcription factor NF-κB pathway by regulating expression of the kinase IKKα during macrophage differentiation
Tao Li, Michael J Morgan, Swati Choksi, Yan Zhang, You-Sun Kim & Zheng-gang Liu
Nature Immunology 11: 799-805; doi:10.1038/ni.1918
Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expression
Hsiangling Teo, Sourav Ghosh, Hendrik Luesch, Arkasubhra Ghosh, Ee Tsin Wong, Najib Malik, Anthony Orth, Paul de Jesus, Anthony S. Perry, Jeffrey D. Oliver, Nhan L. Tran, Lisa J. Speiser, Marc Wong, Enrique Saez, Peter Schultz, Sumit K. Chanda, Inder M. Verma & Vinay Tergaonkar
Nature Cell Biology 12: 758-767; doi:10.1038/ncb2080
Letters
IκBβ acts to inhibit and activate gene expression during the inflammatory response
Ping Rao, Mathew S. Hayden, Meixiao Long, Martin L. Scott, A. Philip West, Dekai Zhang, Andrea Oeckinghaus, Candace Lynch, Alexander Hoffmann, David Baltimore & Sankar Ghosh
Nature 466: 1115-1119; doi:10.1038/nature09283
Single-cell NF-κB dynamics reveal digital activation and analogue information processing
Savaş Tay, Jacob J. Hughey, Timothy K. Lee, Tomasz Lipniacki, Stephen R. Quake & Markus W. Covert
Nature 466: 267-271; doi:10.1038/nature09145
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
Sergio E. Alvarez, Kuzhuvelil B. Harikumar, Nitai C. Hait, Jeremy Allegood, Graham M. Strub, Eugene Y. Kim, Michael Maceyka, Hualiang Jiang, Cheng Luo, Tomasz Kordula, Sheldon Milstien & Sarah Spiegel
Nature 465: 1084-1088; doi:10.1038/nature09128
B-cell-derived lymphotoxin promotes castration-resistant prostate cancer
Massimo Ammirante, Jun-Li Luo, Sergei Grivennikov, Sergei Nedospasov & Michael Karin
Nature 464: 302-305; doi:10.1038/nature08782
Regulation of NF-κB inhibitor IκBα and viral replication by a KSHV microRNA
Xiufen Lei, Zhiqiang Bai, Fengchun Ye, Jianping Xie, Chan-Gil Kim, Yufei Huang & Shou-Jiang Gao
Nature Cell Biology 12: 193-199; doi:10.1038/ncb2019
A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKγ to dampen the host NF-κB-mediated inflammatory response
Hiroshi Ashida, Minsoo Kim, Marc Schmidt-Supprian, Averil Ma, Michinaga Ogawa & Chihiro Sasakawa
Nature Cell Biology 12: 66-73; doi:10.1038/ncb2006
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