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Volume 21 Issue 1, January 2011

Editorial

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Research Highlight

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Review

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Original Article

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  • Celiac disease is an intestinal inflammatory disorder that occurs in genetically predisposed individuals and causes intolerance to wheat protein gluten and related proteins (prolamines) that are contained in barley and rye. Histologically, the small bowel mucosa in celiac disease shows villous atrophy (lost of villi), crypt hyperplasia and lymphocyte infiltration. To allow better understand the histological damage that occurs during mucosal changes Marsh proposed a series of stages to aid diagnostics: Marsh I represents lymphocytic enteritis, Marsh II represents lymphocytic enteritis with crypt hyperplasia, and Marsh III represents partial (a), subtotal (b) and total (c) villous atrophy. These changes are accompanied by a gradual increase in the number of T cells and activation of immunoregulatory counteractions in the diseased mucosa. The March 2011 special issue on celiac sprue and mucosal immunity presents some of the latest advances in celiac disease diagnostics; the web focus further expands our understanding of this inflammatory disorder through a collection of recent articles from across Springer Nature.

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  • The NF-κB pathway plays an important role in regulating diverse biological processes, including the immune response, inflammation, cell growth and survival, and development. Deregulation of the NF-κB pathway leads to diseases such as autoimmunity and cancer. The January 2011 special issue on NF-κB signaling brings our understanding of this important pathway up-to-date, focusing on the NF-κB signaling mechanisms and their role in physiology and diseases. The accompanying web focus presents links to related articles from across Nature Publishing Group to provide more background information about the pathway.

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