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Integrating sex and gender in mental health research: enhanced funding for better treatments

Sex and gender play an important role in mental health. Clinical and preclinical research for novel treatments need to take this serious matter under consideration. The development of safe and effective treatments for specific populations can be achieved only with enhanced and targeted funding that will generate robust and reliable data.

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Fig. 1: Sex and gender play an important role in mental health and in the development of new treatments.

References

  1. Directorate-General for Research and Innovation. Gendered innovation 2: How inclusive analysis contributes to research and innovation. (European Commission, 2020).

  2. National Academies of Sciences, Engineering, and Medicine. Measuring Sex, Gender Identity, and Sexual Orientation. (The National Academies Press, 2022).

  3. Butlen-Ducuing, F. et al. Nat. Rev. Drug Discov. 20, 881–882 (2021).

    Article  PubMed  Google Scholar 

  4. GBD 2019 Mental Disorders Collaborators. Lancet Psychiatry 9, 137–150 (2022).

    Article  PubMed Central  Google Scholar 

  5. Pavlidi, P., Kokras, N. & Dalla, C. Curr. Top. Behav. Neurosci. 62, 103–132 (2023).

    Article  PubMed  Google Scholar 

  6. Goetz, T. G. et al. Neuropsychopharmacology 48, 852–856 (2023).

    Article  PubMed  Google Scholar 

  7. Pawluski, J. L., Kokras, N., Charlier, T. D. & Dalla, C. Eur. J. Neurosci. 52, 2423–2428 (2020).

    Article  PubMed  Google Scholar 

  8. Kokras, N., Hodes, G. E., Bangasser, D. A. & Dalla, C. Br. J. Pharmacol. 176, 4090–4106 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Rechlin, R. K., Splinter, T. F. L., Hodges, T. E., Albert, A. Y. & Galea, L. A. M. Nat. Commun. 13, 2137 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Hentzen, N. B. et al. Eur. J. Neurol. 29, 2572–2579 (2022).

    Article  Google Scholar 

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Correspondence to Christina Dalla.

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C.D. is an unpaid member of the board of Directors of the European Brain Foundation, a member of the FENS Communication Committee, a member of the European College of Neuropsychopharmacology Educational Committee and President-elect of the Mediterranean Neuroscience Society. The views expressed in this commentary are her own and may not be understood or quoted as being made on behalf of the European Brain Foundation or any other organization.

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Dalla, C. Integrating sex and gender in mental health research: enhanced funding for better treatments. Nat. Mental Health 1, 383–384 (2023). https://doi.org/10.1038/s44220-023-00076-2

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