Pregestational diabetes is linked to an increased risk of congenital disorders, including cardiac and craniofacial defects, but the underlying mechanisms are unclear. Using a hyperglycemic mouse model, Nishino et al. show that ectopic retinoic acid signaling in the anterior heart field causes aberrant tissue patterning and associated pathologies1.
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Steimle, J.D., Martin, J.F. Sweet and sour story of maternal diabetes and birth defects. Nat Cardiovasc Res 2, 1107–1108 (2023). https://doi.org/10.1038/s44161-023-00380-1
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DOI: https://doi.org/10.1038/s44161-023-00380-1