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Animal embryogenesis is the process by which the embryo develops from the fertilised egg cell. Important events that occur during embryogenesis are gastrulation, formation of the early nervous system and initiation of organogenesis.
Analysis of global remethylation in mouse embryos at several
developmental stages identifies an epigenetic landscape that partitions extraembryonic
tissues within the embryo and resembles a frequent, global departure in genome
regulation in human cancers.
Ubiquitylation is a post-translational modification that modulates protein stability and regulates various cellular signalling pathways and cellular processes, including cell differentiation, proliferation and migration. Recent insights highlight its crucial role in development and how its deregulation is associated with several diseases.
Ganuza et al. track newly specified blood progenitors in the dorsal aorta of the mouse embryo and demonstrate that they are polyclonal in origin and that hundreds of mesodermal, endothelial and blood precursors establish lifelong haematopoiesis.
Missense mutations affecting lysine 91 in the histone H4 core cause a developmental syndrome marked by growth delay, microcephaly and intellectual disability. These mutations cause genomic instability by interfering with H4K91 ubiquitination, leading to abnormal cell cycle progression and apoptosis during early development.
Understanding of how epigenetic information is acquired, processed and transmitted through cell division, and potentially across generations, remains limited. Mechanistic studies aiming to elucidate the molecular underpinnings of these phenomena may provide insights into development, disease susceptibility and evolution.