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Are plasma markers for Alzheimer’s disease ready for clinical use?

Nature Aging volume 2, pages 94–96 (2022)Cite this article

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Plasma biomarkers pertaining to the underlying pathophysiology of Alzheimer’s disease have recently become available (for example, amyloid beta and phosphorylated tau). The utility of these markers poses a question for clinicians (now and in the future): are plasma biomarkers for Alzheimer’s disease are ready for clinical use at this time?

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Fig. 1: Potential evaluation pathway for a patient being considered for treatment with a disease-modifying therapy for Alzheimer’s disease.

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Acknowledgements

Funding was provided by NIH National Institute on Aging P30 AG062677 and U01 AG006786.

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Authors and Affiliations

  1. Mayo Clinic Alzheimer’s Disease Research Center and Mayo Clinic Study of Aging, Mayo Clinic, Rochester, MN, USA

    Ronald C. Petersen

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  1. Ronald C. Petersen
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R.C.P. is the sole author of this Comment.

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Correspondence to Ronald C. Petersen.

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Competing interests

R.C.P. has consulted for Roche, Inc., Merck, Inc., Biogen, Inc., Eisai, Inc. and Nestle, Inc., and served on a DSMB for Genentech, Inc. R.C.P. has received grants from the National Institute on Aging, the GHR Foundation and the Alzheimer’s Association.

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Petersen, R.C. Are plasma markers for Alzheimer’s disease ready for clinical use?. Nat Aging 2, 94–96 (2022). https://doi.org/10.1038/s43587-022-00176-1

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