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Progress towards the Sustainable Development Goals
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Sertoli cell lysosomes and late-onset hypogonadism
Zhou and colleagues explore reversing testicular aging and late-onset hypogonadism by targeting lysosomal function in Sertoli cells. The aging-related transformation of Sertoli cells into a lipid-hoarding subtype with dysregulated phagolysosomes and autolysosomes was reversed using the TRPML channel agonist ML-SA1, which demonstrates the potential of this targeted therapy in alleviating testosterone decline and systemic male-aging phenotypes.
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Aging, longevity and age-related diseases
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Plasma proteomic profiles predict future dementia in healthy adults
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Human skeletal muscle aging atlas
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Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism
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Spatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition