Ageing

Definition

Ageing is the process during which structural and functional changes accumulate in an organism as a result of the passage of time. The changes manifest as a decline from the organism’s peak fertility and physiological functions until death.

Featured

Latest Research and Reviews

  • Research | | open

    Despite its wide use in ageing research, the contribution of specific age-associated pathologies to C. elegans mortality is not well understood. Here the authors identify two types of death in worms, with either a swollen or a shrunken pharynx, that are differentially affected by age and mutations that extend worm lifespan.

    • Yuan Zhao
    • , Ann F. Gilliat
    • , Matthias Ziehm
    • , Mark Turmaine
    • , Hongyuan Wang
    • , Marina Ezcurra
    • , Chenhao Yang
    • , George Phillips
    • , David McBay
    • , William B. Zhang
    • , Linda Partridge
    • , Zachary Pincus
    •  & David Gems
  • Reviews |

    Sirtuins and the neuron–microglia network have a key role in the ageing process. In this Review article, Satoh and colleagues discuss the role of sirtuins in age-related changes in communication between peripheral tissues and the brain, which has a key influence on ageing and longevity in mammals.

    • Akiko Satoh
    • , Shin-ichiro Imai
    •  & Leonard Guarente
  • Research | | open

    Sister chromatid cohesion during meiosis II (MII), maintained by securin-mediated inhibition of separase, is reduced in aged mouse oocytes. Here the authors show that, in MII oocytes, securin levels are reduced by increased destruction by the anaphase promoting complex/cyclosome.

    • Ibtissem Nabti
    • , Rosanna Grimes
    • , Hema Sarna
    • , Petros Marangos
    •  & John Carroll
  • Research | | open

    Germline mutation rates are known to vary between species but somatic mutation rates are less well understood. Here the authors compare mice and humans, observing that somatic mutation rates were nearly two orders of magnitude higher in both species, with both mutation rates significantly higher in mice.

    • Brandon Milholland
    • , Xiao Dong
    • , Lei Zhang
    • , Xiaoxiao Hao
    • , Yousin Suh
    •  & Jan Vijg
  • Reviews |

    The risk of urinary incontinence and other lower urinary tract (LUT) symptoms increases substantially with advancing age; however, such symptoms can emerge in otherwise healthy individuals. In this Review, the authors describe the changes in LUT physiology that take place during the ageing process, and whether or not these changes arise as a consequence of 'normal', healthy ageing, or unaddressed pathology.

    • William Gibson
    •  & Adrian Wagg

News and Comment