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RNA-modifying enzymes and their function in a chromatin context

Nature Structural & Molecular Biology volume 26, pages 858–862 (2019)Cite this article

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Abstract

Exciting research has connected specific RNA modifications to chromatin, providing evidence for co-transcriptional deposition and function in gene regulation. Here we review insights gained from studying the co-transcriptional roles of RNA modifications, and their influence in normal and disease contexts. We also discuss how the availability of novel technical approaches could raise the translational potential of targeting RNA-modifying enzymes for the treatment of disease.

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  1. The Gurdon Institute and Department of Pathology, University of Cambridge, Cambridge, UK

    Konstantinos Tzelepis & Tony Kouzarides

  2. Storm Therapeutics Ltd, Babraham Research Campus, Cambridge, UK

    Oliver Rausch

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  1. Konstantinos Tzelepis
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T.K. is a co-founder of Abcam and Storm Therapeutics. O.R. is an employee of Storm Therapeutics.

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Tzelepis, K., Rausch, O. & Kouzarides, T. RNA-modifying enzymes and their function in a chromatin context. Nat Struct Mol Biol 26, 858–862 (2019). https://doi.org/10.1038/s41594-019-0312-0

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