RNA

Definition

RNA (ribonucleic acid) is a nucleic acid polymer where the carbohydrate is ribose. RNA is generally single-stranded, as DNA is transcribed by RNA polymerases into mRNA (messenger RNA), which is read by ribosomes to generate protein (translation). Biologically active RNAs, including transport, ribosomal and small nuclear RNA (tRNA, rRNA, snRNAs) fold into unique structures guided by complementary pairing between nucleotide bases.

Latest Research and Reviews

  • Research |

    Structural ensembles of the 70S ribosome bound to cognate or near-cognate charged tRNAs in complex with EF-Tu illustrate the crucial role of the nucleotide G530 in decoding of mRNA, and demonstrate that translational fidelity results from direct control of GTPase by the decoding centre.

    • Anna B. Loveland
    • , Gabriel Demo
    • , Nikolaus Grigorieff
    •  & Andrei A. Korostelev
  • Research |

    Iterative oxidation, elimination and dephosphorylation steps remove nucleotides from the 3′ end of RNA until a 2′-O-methylated ribose that cannot be oxidized is encountered and brings the process to a stop. High-throughput sequencing of these fragments exposes 2′-O-methyl sites at base resolution.

    • Qing Dai
    • , Sharon Moshitch-Moshkovitz
    • , Dali Han
    • , Nitzan Kol
    • , Ninette Amariglio
    • , Gideon Rechavi
    • , Dan Dominissini
    •  & Chuan He
  • Research | | open

    A single variant in mir-30c-1 found in breast and gastric cancer patients leads to increased levels of mature miRNA. Here the authors show that this variant alters the RNA structure of this pri-miRNA leading to enhanced binding of SRSF3 and increased Drosha-mediated processing.

    • Noemi Fernandez
    • , Ross A. Cordiner
    • , Robert S. Young
    • , Nele Hug
    • , Sara Macias
    •  & Javier F. Cáceres
  • Research |

    Structural characterization sheds mechanistic insights behind λN-dependent processive antitermination.

    • Nelly Said
    • , Ferdinand Krupp
    • , Ekaterina Anedchenko
    • , Karine F. Santos
    • , Olexandr Dybkov
    • , Yong-Heng Huang
    • , Chung-Tien Lee
    • , Bernhard Loll
    • , Elmar Behrmann
    • , Jörg Bürger
    • , Thorsten Mielke
    • , Justus Loerke
    • , Henning Urlaub
    • , Christian M. T. Spahn
    • , Gert Weber
    •  & Markus C. Wahl

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