Traditional production of therapeutic secretory proteins often experiences delays between protein synthesis and therapeutic effects. An inducible protease-dependent protein secretion technique allows the immediate secretion of pre-translated biotherapeutic agents after exposure to chemical cues, tumor-specific antigens or photons.
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References
Benham, A. M. Cold Spring Harb. Perspect. Biol. 4, a012872 (2012).
Wang, X. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01433-z (2023).
Higashikuni, Y., Chen, W. C. & Lu, T. K. Curr. Opin. Biotechnol. 47, 133–141 (2017).
Morsut, L. et al. Cell 164, 780–791 (2016).
Stanton, B. Z., Chory, E. J. & Crabtree, G. R. Science 359, 6380 (2018).
Lan, T. H., He, L., Huang, Y. & Zhou, Y. Trends. Genet. 38, 1253–1270 (2022).
Boncompain, G. et al. Nat. Methods 9, 493–498 (2012).
Praznik, A. et al. Nat. Commun. 13, 1323 (2022).
Vlahos, A. E. et al. Nat. Commun. 13, 912 (2022).
Tan, P., He, L., Huang, Y. & Zhou, Y. Physiol. Rev. 102, 1263–1325 (2022).
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Wang, T., Zhou, Y. A PASS for protein secretion. Nat Chem Biol 20, 396–398 (2024). https://doi.org/10.1038/s41589-023-01444-w
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DOI: https://doi.org/10.1038/s41589-023-01444-w