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Vasculitis

Platelets promote cardiovascular complications in Kawasaki disease

Nature Reviews Rheumatology volume 19, page 537 (2023)Cite this article

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Kawasaki disease is a childhood vasculitis characterized by inflammation of blood vessels, including coronary arteries, and is a leading cause of heart disease among children. New research provides mechanistic insight into how platelets contribute to the development of cardiovascular lesions in Kawasaki disease.

“Increased platelet count (thrombocytosis) is a common feature of Kawasaki disease and is typically reported in the second or third week after disease onset, usually when coronary artery aneurysms appear,” explains Moshe Arditi, corresponding author on the study. “However, the role of platelets in the pathogenesis, development, progression and severity of cardiovascular lesions during Kawasaki disease is not well understood.”

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References

Original article

  • Kocatürk, B. et al. Platelets exacerbate cardiovascular inflammation in a murine model of Kawasaki disease vasculitis. JCI Insight 8, e169855 (2023)

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  1. Nature Reviews Rheumatology http://www.nature.com/nrrheum/

    Jessica McHugh

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  1. Jessica McHugh
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Correspondence to Jessica McHugh.

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McHugh, J. Platelets promote cardiovascular complications in Kawasaki disease. Nat Rev Rheumatol 19, 537 (2023). https://doi.org/10.1038/s41584-023-01011-6

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  • DOI: https://doi.org/10.1038/s41584-023-01011-6

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