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Cartilage regeneration in 2022

New refinements aim to optimize articular cartilage tissue engineering

Nature Reviews Rheumatology volume 19, pages 66–67 (2023)Cite this article

Subjects

Successful, long-term treatment of articular cartilage injuries is important for the prevention of osteoarthritis but remains a major challenge. Three studies in 2022 highlight new approaches to improving articular cartilage regeneration.

Key advances

  • A synthetic artificial stem cell (SASC) system, designed to mimic the secretome of mesenchymal stem cells, attenuated cartilage degeneration and improves the biomechanical properties of articular cartilage in vivo3.

  • A zonal microstructured scaffold proved to be robust and mechanically stable in a large-animal model of osteochondral defects4.

  • Scaffolds derived from solubilized articular cartilage extracellular matrix were able to successfully repair chondral lesions, particularly when loaded with TGFβ3 (ref. 5).

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Fig. 1: Three new therapeutic strategies for articular cartilage regeneration.

References

  1. Hunter, D. J. & Bierma-Zeinstra, S. Osteoarthritis. Lancet 393, 1745–1759 (2019).

    Article  CAS  Google Scholar 

  2. Makris, E. A., Gomoll, A. H., Malizos, K. N., Hu, J. C. & Athanasiou, K. A. Repair and tissue engineering techniques for articular cartilage. Nat. Rev. Rheumatol. 11, 21–34 (2015).

    Article  CAS  Google Scholar 

  3. Shah, S., Esdaille, C. J., Bhattacharjee, M., Kan, H. M. & Laurencin, C. T. The synthetic artificial stem cell (SASC): shifting the paradigm of cell therapy in regenerative engineering. Proc. Natl. Acad. Sci. USA 119, e2116865118 (2022).

    Article  CAS  Google Scholar 

  4. Steele, J. A. M. et al. In vitro and in vivo investigation of a zonal microstructured scaffold for osteochondral defect repair. Biomaterials 286, 121548 (2022).

    Article  CAS  Google Scholar 

  5. Browe, D. C. et al. Promoting endogenous articular cartilage regeneration using extracellular matrix scaffolds. Mater. Today Bio. 16, 100343 (2022).

    Article  CAS  Google Scholar 

  6. Krawetz, R. J. et al. Synovial mesenchymal progenitor derived aggrecan regulates cartilage homeostasis and endogenous repair capacity. Cell Death Dis. 13, 470 (2022).

    Article  CAS  Google Scholar 

  7. Ajeeb, B., Acar, H. & Detamore, M. S. Chondroinductive peptides for cartilage regeneration. Tissue Eng. Part B. Rev. 28, 745–765 (2022).

    Article  CAS  Google Scholar 

  8. Campbell, T. M., Dilworth, F. J., Allan, D. S. & Trudel, G. The hunt is on! In pursuit of the ideal stem cell population for cartilage regeneration. Front. Bioeng. Biotechnol. 10, 866148 (2022).

    Article  Google Scholar 

  9. Lach, M. S. et al. The induced pluripotent stem cells in articular cartilage regeneration and disease modelling: are we ready for their clinical use? Cells 11, 529 (2022).

    Article  CAS  Google Scholar 

  10. Herrmann, M. et al. Extracellular vesicles in musculoskeletal pathologies and regeneration. Front. Bioeng. Biotechnol. 8, 624096 (2021).

    Article  Google Scholar 

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Authors and Affiliations

  1. Experimental Orthopaedics, Centre for Medical Biotechnology (ZMB), University of Regensburg, Bavaria, Germany

    Nicole Schäfer & Susanne Grässel

  2. Department of Orthopaedic Surgery, University of Regensburg, Bavaria, Germany

    Susanne Grässel

Authors
  1. Nicole Schäfer
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  2. Susanne Grässel
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Correspondence to Susanne Grässel.

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The authors declare no competing interests.

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Schäfer, N., Grässel, S. New refinements aim to optimize articular cartilage tissue engineering. Nat Rev Rheumatol 19, 66–67 (2023). https://doi.org/10.1038/s41584-022-00889-y

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