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SYSTEMIC SCLEROSIS

FGF signalling enters the SSc arena

Nature Reviews Rheumatology volume 16, page 665 (2020)Cite this article

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Systemic sclerosis (SSc) is typified by fibrosis in multiple organs that can eventually lead to organ failure. Although some of the signalling pathways involved in fibrosis are understood, their importance can vary from organ to organ, and attempts to target individual pro-fibrotic factors have so far failed.

“Our findings indicate that aberrant FGFR3 signalling plays a crucial role in fibrotic tissue remodelling in SSc,” states lead author Debomita Chakraborty. “However, considering the complex pathogenesis and the heterogeneity of SSc, further in vivo studies with additional patient samples from other cohorts are required to confirm these findings in different clinical subtypes of SSc,” she cautions.

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References

Original article

  • Chakraborty, D. et al. Fibroblast growth factor receptor 3 activates a network of profibrotic signaling pathways to promote fibrosis in systemic sclerosis. Sci. Transl Med. 12, eaaz5506 (2020)

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  1. Nature Reviews Rheumatology http://www.nature.com/nrrheum/

    Joanna Clarke

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  1. Joanna Clarke
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Correspondence to Joanna Clarke.

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Clarke, J. FGF signalling enters the SSc arena. Nat Rev Rheumatol 16, 665 (2020). https://doi.org/10.1038/s41584-020-00536-4

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  • DOI: https://doi.org/10.1038/s41584-020-00536-4

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