In 2021, transcriptome analysis of the mouse and human gut advanced our understanding of the cellular composition, development and surrounding non-neural context of the enteric nervous system (ENS). A role for the ENS in tuning regulatory T cell proportions contributed insights into the dependency between the ENS, immune system and microbiota.
Key advances
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Single-cell transcriptome analysis and histochemistry revealed 12 myenteric neuron classes in the mouse small intestine and a conceptually new step-wise principle for their embryonic diversification5.
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A monumental single-cell transcriptome atlas of the human gut across time and space described the development of the enteric nervous system (ENS) and the non-neural cellular context of the fetal, paediatric and adult ENS7.
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Enteric neurons tune the number and phenotypes of regulatory T cells by secretion of IL-6; in turn, the structure and activity of the ENS is modulated by microbial signals, altogether suggesting tripartite interactions between the ENS, immune system and microbiota, of relevance for intestinal tolerance10.
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Acknowledgements
The laboratory of U.M. is supported by the Swedish Research Council (2020-01129), Knut & Alice Wallenberg Foundation (2020.0109), NIH, Brain Foundation, Ollie and Elof Ericsson’s Foundation, and SFO Stem Cells and Regeneration.
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Marklund, U. Diversity, development and immunoregulation of enteric neurons. Nat Rev Gastroenterol Hepatol 19, 85–86 (2022). https://doi.org/10.1038/s41575-021-00553-y
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DOI: https://doi.org/10.1038/s41575-021-00553-y