Enteric nervous system

Definition

The enteric nervous system is the part of the autonomic nervous system that controls visceral functions, including the functioning of the gastrointestinal tract, pancreas and gallbladder.

Latest Research and Reviews

  • Research |

    Group 2 innate lymphoid cells express the neuromedin U receptor 1 (NMUR1) and respond to neuromedin U (NMU) released by adjacent enteric neurons, and this interaction results in an enhanced immediate early response to the nematode Nippostrongylus brasiliensis.

    • Vânia Cardoso
    • , Julie Chesné
    • , Hélder Ribeiro
    • , Bethania García-Cassani
    • , Tânia Carvalho
    • , Tiffany Bouchery
    • , Kathleen Shah
    • , Nuno L. Barbosa-Morais
    • , Nicola Harris
    •  & Henrique Veiga-Fernandes
    Nature 549, 277–281
  • Reviews |

    Serotonin is a key intercellular signalling molecule with well-known functions in the gastrointestinal tract, particularly for motility. This Review explores the non-conventional roles of gut-derived serotonin in the gut and other peripheral tissues, including during gastrointestinal inflammation, haematopoiesis, metabolic homeostasis and bone remodelling.

    • Stephanie N. Spohn
    •  & Gary M. Mawe
  • Research |

    Organoids formed by combining pluripotent-stem-cell-derived human neural crest cells with pluripotent-stem-cell-derived intestinal tissue show functional interstitial cells of Cajal and undergo waves of contraction; these tissues reveal insights into the molecular defects characterizing Hirschsprung's disease.

    • Michael J Workman
    • , Maxime M Mahe
    • , Stephen Trisno
    • , Holly M Poling
    • , Carey L Watson
    • , Nambirajan Sundaram
    • , Ching-Fang Chang
    • , Jacqueline Schiesser
    • , Philippe Aubert
    • , Edouard G Stanley
    • , Andrew G Elefanty
    • , Yuichiro Miyaoka
    • , Mohammad A Mandegar
    • , Bruce R Conklin
    • , Michel Neunlist
    • , Samantha A Brugmann
    • , Michael A Helmrath
    •  & James M Wells
    Nature Medicine 23, 49–59
  • Reviews |

    The enteric nervous system is vital for life, and its dysfunction participates not only in digestive disorders, but also in diseases of the central nervous system (CNS). Here, Rao and Gershon discuss the gastrointestinal consequences of neurological disorders, the acquisition of CNS disease in the gut and the spread of pathology along the gut–brain axis.

    • Meenakshi Rao
    •  & Michael D. Gershon

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