Correction to: Laboratory Investigation
Three different clarifications are warranted to better understand our findings and conclusions.
(1) On page 9 in the PDF version, subtitle “Medium acidification has less influence on Ca2+ regulation” should instead read:
Role of Asc-induced acidification in increasing Ca2+ influx
Section summary clarification: The role was reevaluated of Asc-induced medium acidification in contributing to increases in Ca2+ influx. We wish to clarify that the responses to Asc were much larger than those induced by medium acidification. Therefore, lowering the pH does not account for how Asc increases intracellular Ca2+ influx.
(2) Subtitle for Fig. 10 should be corrected as:
Acidifying-induced Ca2+ transients in etoposide-resistant and -sensitive WERI-Rb1 cells
(3) The following alteration is more precise regarding the role of TRPV1 channel activation during medium acidification. (page 11 - paragraph 2 and page 14 - paragraph 3; PDF version):
Section summary clarification: TRPV1 activation does not contribute to the small increases in Ca2+ influx resulting from medium acidification. This channel is not involved since the decline in pH occurred over a range known not to alter its activity. We suggest that mechanisms other than acidification are the main contributors underlying Asc–induced Ca2+ transients. Moreover, WERI-Rb1 cells possibly possess other pH sensitive pathways since lowering the pH induced significant increases in Ca2+ influx.
These corrections do not affect the results and conclusions of the article.
All authors agree with the corrections.
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The original article can be found online at https://doi.org/10.1038/s41374-020-00485-2.
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Oronowicz, J., Reinhard, J., Reinach, P.S. et al. Correction: Ascorbate-induced oxidative stress mediates TRP channel activation and cytotoxicity in human etoposide-sensitive and -resistant retinoblastoma cells. Lab Invest 101, 1112 (2021). https://doi.org/10.1038/s41374-020-00499-w
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DOI: https://doi.org/10.1038/s41374-020-00499-w
