The largest GWAS (genome-wide association study) of SLE (systemic lupus erythematosus) to date has mapped 43 identified loci, including 10 new variants (mostly in enzyme genes). Of note, 16 of the SLE-linked genes encode transcription factors—more than would be expected by chance. The researchers genotyped 7,219 patients and 15,991 healthy controls of European ancestry for this new GWAS and supporting studies.
References
Bentham, J. et al. Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus. Nat. Genet. doi:10.1038/ng.3434
Rights and permissions
About this article
Cite this article
New GWAS data link aberrant immunoregulation to SLE. Nat Rev Rheumatol 11, 682 (2015). https://doi.org/10.1038/nrrheum.2015.154
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrrheum.2015.154
