Systemic lupus erythematosus

Definition

Systemic lupus erythematosus is a potentially fatal autoimmune disease that is characterized by wide-spread inflammation and tissue damage that can affect any part of the body. Commonly affected sites include the liver, kidneys, blood vessels, skin, heart and joints. Patients are treated with immunosuppressive drugs.

Latest Research and Reviews

  • Research | | open

    Excessive expansion of the T follicular helper (TFH) cell pool is associated with autoimmune disease and Def6 has been identified as an SLE risk variant. Here the authors show that Def6 limits proliferation of TFH cells in mice via alteration of mTORC1 signaling and inhibition of Bcl6 expression.

    • Woelsung Yi
    • , Sanjay Gupta
    • , Edd Ricker
    • , Michela Manni
    • , Rolf Jessberger
    • , Yurii Chinenov
    • , Henrik Molina
    •  & Alessandra B. Pernis
  • Research | | open

    • Jonas Carlsson Almlöf
    • , Andrei Alexsson
    • , Juliana Imgenberg-Kreuz
    • , Lina Sylwan
    • , Christofer Bäcklin
    • , Dag Leonard
    • , Gunnel Nordmark
    • , Karolina Tandre
    • , Maija-Leena Eloranta
    • , Leonid Padyukov
    • , Christine Bengtsson
    • , Andreas Jönsen
    • , Solbritt Rantapää Dahlqvist
    • , Christopher Sjöwall
    • , Anders A. Bengtsson
    • , Iva Gunnarsson
    • , Elisabet Svenungsson
    • , Lars Rönnblom
    • , Johanna K. Sandling
    •  & Ann-Christine Syvänen
  • Research | | open

    Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong ethnic and gender bias. In a transancestral genetic association study, Langefeld et al. identify 24 novel regions associated with risk to lupus and propose a cumulative hits hypothesis for loci conferring risk to SLE.

    • Carl D. Langefeld
    • , Hannah C. Ainsworth
    • , Deborah S. Cunninghame Graham
    • , Jennifer A. Kelly
    • , Mary E. Comeau
    • , Miranda C. Marion
    • , Timothy D. Howard
    • , Paula S. Ramos
    • , Jennifer A. Croker
    • , David L. Morris
    • , Johanna K. Sandling
    • , Jonas Carlsson Almlöf
    • , Eduardo M. Acevedo-Vásquez
    • , Graciela S. Alarcón
    • , Alejandra M. Babini
    • , Vicente Baca
    • , Anders A. Bengtsson
    • , Guillermo A. Berbotto
    • , Marc Bijl
    • , Elizabeth E. Brown
    • , Hermine I. Brunner
    • , Mario H. Cardiel
    • , Luis Catoggio
    • , Ricard Cervera
    • , Jorge M. Cucho-Venegas
    • , Solbritt Rantapää Dahlqvist
    • , Sandra D’Alfonso
    • , Berta Martins Da Silva
    • , Iñigo de la Rúa Figueroa
    • , Andrea Doria
    • , Jeffrey C. Edberg
    • , Emőke Endreffy
    • , Jorge A. Esquivel-Valerio
    • , Paul R. Fortin
    • , Barry I. Freedman
    • , Johan Frostegård
    • , Mercedes A. García
    • , Ignacio García de la Torre
    • , Gary S. Gilkeson
    • , Dafna D. Gladman
    • , Iva Gunnarsson
    • , Joel M. Guthridge
    • , Jennifer L. Huggins
    • , Judith A. James
    • , Cees G. M. Kallenberg
    • , Diane L. Kamen
    • , David R. Karp
    • , Kenneth M. Kaufman
    • , Leah C. Kottyan
    • , László Kovács
    • , Helle Laustrup
    • , Bernard R. Lauwerys
    • , Quan-Zhen Li
    • , Marco A. Maradiaga-Ceceña
    • , Javier Martín
    • , Joseph M. McCune
    • , David R. McWilliams
    • , Joan T. Merrill
    • , Pedro Miranda
    • , José F. Moctezuma
    • , Swapan K. Nath
    • , Timothy B. Niewold
    • , Lorena Orozco
    • , Norberto Ortego-Centeno
    • , Michelle Petri
    • , Christian A. Pineau
    • , Bernardo A. Pons-Estel
    • , Janet Pope
    • , Prithvi Raj
    • , Rosalind Ramsey-Goldman
    • , John D. Reveille
    • , Laurie P. Russell
    • , José M. Sabio
    • , Carlos A. Aguilar-Salinas
    • , Hugo R. Scherbarth
    • , Raffaella Scorza
    • , Michael F. Seldin
    • , Christopher Sjöwall
    • , Elisabet Svenungsson
    • , Susan D. Thompson
    • , Sergio M. A. Toloza
    • , Lennart Truedsson
    • , Teresa Tusié-Luna
    • , Carlos Vasconcelos
    • , Luis M. Vilá
    • , Daniel J. Wallace
    • , Michael H. Weisman
    • , Joan E. Wither
    • , Tushar Bhangale
    • , Jorge R. Oksenberg
    • , John D. Rioux
    • , Peter K. Gregersen
    • , Ann-Christine Syvänen
    • , Lars Rönnblom
    • , Lindsey A. Criswell
    • , Chaim O. Jacob
    • , Kathy L. Sivils
    • , Betty P. Tsao
    • , Laura E. Schanberg
    • , Timothy W. Behrens
    • , Earl D. Silverman
    • , Timothy J. Vyse
    • , Robert R. Graham
    • , Edward K. Wakeland
    • , Robert P. Kimberly
    • , John B. Harley
    • , Patrick M. Gaffney
    •  & Marta E. Alarcón-Riquelme
  • Reviews |

    Current treatment recommendations for lupus nephritis are largely guided by the 2003 International Society of Nephrology/Renal Pathology Society classification system. Here, the authors discuss potential approaches by which this classification system could be improved through consideration of underlying disease processes characterized by the presence of glomerular crescents, podocyte injury, tubulointerstitial lesions and vascular injury.

    • Feng Yu
    • , Mark Haas
    • , Richard Glassock
    •  & Ming-Hui Zhao

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