Schizophrenia is associated with several cognitive deficits, and the authors investigated whether prodromal cognitive training could reduce or prevent such deficits. They used a neonatal ventral hippocampal lesion rat model of schizophrenia — in adulthood, these rats have cognitive control impairments and altered intrahippocampal synchrony of neural oscillations. Cognitive training during adolescence prevented these abnormalities, pointing to a possible prophylactic strategy for people at risk of schizophrenia.
ORIGINAL RESEARCH PAPER
Lee, H. et al. Early cognitive experience prevents adult deficits in a neurodevelopmental schizophrenia model. Neuron 75, 714–724 (2012)
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Welberg, L. Cognitive prophylaxis for schizophrenia?. Nat Rev Neurosci 13, 669 (2012). https://doi.org/10.1038/nrn3349
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DOI: https://doi.org/10.1038/nrn3349